Direct evidence for the link between monoaminergic descending pathways and motor activity: II. A study with microdialysis probes implanted in the ventral horn of the spinal cord

Brain Research
C Gerin, A Privat

Abstract

In order to define precisely the relation between descending monoaminergic systems and the motor system, we measured in the ventral horn of spinal cord of adult rats the variations of extracellular concentrations of 5-HT, 5-HIAA, DA and MHPG. Measurements were performed during rest, endurance running on a treadmill, and a post-exercise period, with microdialysis probes implanted permanently for 45 days. We found a slight decrease in both 5-HT and 5-HIAA during locomotion with a more marked decrease during the post-exercise period compared to the mean of rest values. In contrast, the concentration of DA and MHPG increased slightly during the exercise and decreased thereafter. These results, when compared with those of a previous study, which measured monoamines in the spinal cord white matter [C. Gerin, D. Bécquet, A. Privat, Direct evidence for the link between monoaminergic descending pathways and motor activity: I. A study with microdialysis probes implanted in the ventral funiculus of the spinal cord, Brain Res. 704 (1995) 191-201], highlight the complex regulation of the release of monoamines that occurs in the ventral horn.

Citations

Sep 21, 2012·Journal of Neurophysiology·Jennifer M Humphreys, Patrick J Whelan
Jun 10, 2011·Journal of Neurophysiology·Peter B Schwarz, John H Peever
Oct 25, 2014·PloS One·Kathrin KoblingerPatrick J Whelan
Jul 2, 2014·Frontiers in Neural Circuits·Simon A SharplesPatrick J Whelan
Dec 12, 2001·Sports Medicine·R MeeusenK De Meirleir
Jan 21, 2006·The Journal of Physiology·Andrew J FuglevandDouglas A Keen
Sep 19, 2012·Journal of Pharmacological Sciences·Alba Vidal-TorresBegoña Fernández-Pastor
Feb 6, 2015·Journal of Neurophysiology·Simon A SharplesPatrick J Whelan
Sep 29, 2017·Journal of Neurophysiology·David Acton, Gareth B Miles
Dec 9, 2008·Journal of Neurotrauma·Oliver MaricVolker Dietz
Oct 13, 2018·British Journal of Psychology·Gordon DodwellThomas Töllner
Oct 27, 2018·Frontiers in Neural Circuits·Kathrin KoblingerPatrick J Whelan
Dec 31, 1998·Current Opinion in Neurology·M Giménez y Ribotta, A Privat
Mar 4, 2003·Journal of Neurophysiology·Ian D HentallBrian R Noga
Dec 30, 2006·Muscle & Nerve·Michael A NordstromDouglas G Stuart
Apr 15, 2005·Journal of Neurophysiology·Kimberly J Christie, Patrick J Whelan
Mar 16, 2004·The European Journal of Neuroscience·Grégory BarrièreJean-René Cazalets
Feb 16, 2008·Neuromolecular Medicine·Teresa E Foley, Monika Fleshner
Jan 8, 2015·Journal of Motor Behavior·Amaya M Singh, W Richard Staines

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