Direct Evidence of Acetaminophen Interference with Subcutaneous Glucose Sensing in Humans: A Pilot Study

Diabetes Technology & Therapeutics
Ananda BasuRita Basu

Abstract

Recent advances in accuracy and reliability of continuous glucose monitoring (CGM) devices have focused renewed interest on the use of such technology for therapeutic dosing of insulin without the need for independent confirmatory blood glucose meter measurements. An important issue that remains is the susceptibility of CGM devices to erroneous readings in the presence of common pharmacologic interferences. We report on a new method of assessing CGM sensor error to pharmacologic interferences using the example of oral administration of acetaminophen. We examined the responses of several different Food and Drug Administration-approved and commercially available CGM systems (Dexcom [San Diego, CA] Seven(®) Plus™, Medtronic Diabetes [Northridge, CA] Guardian(®), and Dexcom G4(®) Platinum) to oral acetaminophen in 10 healthy volunteers without diabetes. Microdialysis catheters were placed in the abdominal subcutaneous tissue. Blood and microdialysate samples were collected periodically and analyzed for glucose and acetaminophen concentrations before and after oral ingestion of 1 g of acetaminophen. We compared the response of CGM sensors with the measured acetaminophen concentrations in the blood and interstitial fluid. Although pl...Continue Reading

References

Jul 27, 2001·Diabetes Technology & Therapeutics·Z TangG J Kost
Jul 21, 2009·Diabetes Technology & Therapeutics·Geoffrey McGarraugh
Apr 15, 2014·Annals of the New York Academy of Sciences·Thomas PeyserJay S Skyler
Apr 25, 2014·Diabetes Technology & Therapeutics·Timothy S BaileyScott W Lee
Oct 12, 2014·Journal of Diabetes Science and Technology·Ananda BasuRita Basu
Nov 6, 2014·Journal of Diabetes Science and Technology·Timothy S BaileyMark Christiansen
Dec 2, 2014·Diabetes Technology & Therapeutics·Boris P KovatchevMarc D Breton
Aug 14, 2015·Diabetes Care·David M MaahsBruce Buckingham

❮ Previous
Next ❯

Citations

Mar 24, 2017·Journal of Diabetes Science and Technology·Ananda BasuRita Basu
May 26, 2017·Diabetes Technology & Therapeutics·Rayhan A Lal, David M Maahs
Jun 7, 2017·Diabetes Technology & Therapeutics·Sarit Polsky, Rachel Garcetti
Jun 14, 2017·Pediatric Transplantation·Deborah A ElderJaimie D Nathan
Jan 18, 2018·Journal of Diabetes Science and Technology·Peter CalhounAndrew K Balo
Jan 19, 2018·Journal of the Endocrine Society·Grazia AleppoDennis R Harris
Aug 4, 2018·Journal of Diabetes Science and Technology·Ryan BoehmIrada Isayeva
Jul 25, 2019·Diabetes Technology & Therapeutics·Stefan PleusGuido Freckmann
May 20, 2017·Journal of Applied Physiology·Melissa L EricksonNathan T Jenkins
Aug 18, 2017·Diabetes Technology & Therapeutics·Vikash Dadlani, Yogish C Kudva
May 16, 2019·JAMA : the Journal of the American Medical Association·Anastasia-Stefania AlexopoulosAnne L Peters
May 27, 2020·Endocrine Reviews·Rodolfo J GalindoKatherine R Tuttle
Aug 3, 2017·Diabetes Technology & Therapeutics·Jessica R Castle
Jan 14, 2020·Expert Review of Endocrinology & Metabolism·Jenine Y Stone, Timothy S Bailey
Jan 20, 2016·Diabetes Technology & Therapeutics·Satish K Garg
Jun 25, 2020·International Ophthalmology Clinics·Janet H Leung, Ella H Leung
May 16, 2017·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Sverre Christian ChristiansenSven Magnus Carlsen
Oct 16, 2020·Expert Opinion on Pharmacotherapy·Syed Shahzad HasanMuhammad Abdul Hadi
Jun 13, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·George GrunbergerJeff Unger
Dec 17, 2021·Journal of Diabetes Science and Technology·Lutz Heinemann

❮ Previous
Next ❯

Methods Mentioned

BETA
pregnancy test

Software Mentioned

FreeStyle Navigator
FreeStyle ® Navigator

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.