Sep 2, 2014

Direct gamete sequencing reveals no evidence for segregation distortion in house mouse hybrids

bioRxiv
Russ Corbett-DetigHopi Hoekstra

Abstract

Understanding the molecular basis of species formation is an important goal in evolutionary genetics, and Dobzhansky-Muller incompatibilities are thought to be a common source of postzygotic reproductive isolation between closely related lineages. However, the evolutionary forces that lead to the accumulation of such incompatibilities between diverging taxa are poorly understood. Segregation distorters are believed to be an important source of Dobzhansky-Muller incompatibilities between Drosophila species and crop plants, but it remains unclear if these selfish genetic elements contribute to reproductive isolation in other species. Here, we collected viable sperm from first-generation hybrid male progeny of Mus musculus castaneus and M. m. domesticus , two subspecies of rodent in the earliest stages of speciation. We then genotyped millions of single nucleotide polymorphisms in these gamete pools and tested for a skew in the frequency of parental alleles across the genome. We show that segregation distorters are not measurable contributors to observed infertility in these hybrid males, despite sufficient statistical power to detect even weak segregation distortion with our novel method. Thus, reduced hybrid male fertility in cr...Continue Reading

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Mentioned in this Paper

Fertility
Banding of Pulmonary Artery
Crops, Agricultural
Genome
Isolation Aspects
Infertility Study
Sperm Cell
Avian Crop
Nucleic Acid Sequencing
House mice

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