Direct gene delivery to murine testis as a possible means of transfection of mature sperm and epithelial cells lining epididymal ducts

Reproductive Medicine and Biology
Masahiro Sato

Abstract

The use of a sperm cell to introduce exogenous DNA into an oocyte at the time of fertilization is of interest for the simple production of transgenic mice, and is now called 'sperm-mediated gene transfer (SMGT)'. In vivo transfection of sperm cells has been developed as an alternative method for SMGT and can be carried out by direct gene delivery into an interstitial space in a testis (now called 'testis-mediated gene transfer [TMGT]'), into the vas deferens, or into seminiferous tubules. This review summarizes what has been achieved in the field of in vivo gene transfer using sperm cells. (Reprod Med Biol 2006; 5: 1-7).

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Citations

Nov 27, 2018·Reproduction in Domestic Animals = Zuchthygiene·Chatwalee BoonthumTeerapong Yata

Related Concepts

DNA
Epithelial Cells
Fertility
Mice, Transgenic
Mus
Oocytes
Sperm Cell
Testis
Transfection
Interstitial Space

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