PMID: 8457292Jan 1, 1993Paper

Direct growth stimulation of normal human epithelial cells by mutant p53

Molecular Carcinogenesis
F S WyllieD Wynford-Thomas

Abstract

We developed a high-titer amphotropic retroviral vector that expresses mutant (Ala143) human p53 to test directly the response of genetically normal human epithelial cells to p53 mutation. Contrary to our prediction, we found that in pancreatic epithelium (whose tumors display a high frequency of p53 mutation) but not in thyroid (whose tumors show an exceptionally low mutation frequency), expression of mutant p53 induced a dramatic, though self-limiting, proliferative response. This result questions the assumption that p53 mutation is relevant only to the later stages of tumorigenesis.

References

Feb 1, 1992·The Journal of Pathology·P A Hall, N R Lemoine
Jan 1, 1992·Genes, Chromosomes & Cancer·C Caron de Fromentel, T Soussi
Sep 1, 1991·Genes, Chromosomes & Cancer·R ChungR Martuza
Oct 1, 1990·Molecular and Cellular Biology·D Wynford-ThomasN R Lemoine
Dec 1, 1991·British Journal of Cancer·C M BartonR C Williamson
Mar 1, 1991·Molecular and Cellular Biology·G G HicksM Mowat
Jun 6, 1991·Nature·A J LevineC A Finlay
Jan 1, 1990·Genes & Development·D P Lane, S Benchimol
May 1, 1989·British Journal of Cancer·J S BurnsD Wynford-Thomas
May 1, 1987·Molecular and Cellular Endocrinology·D W WilliamsE D Williams
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·O Danos, R C Mulligan
Sep 1, 1984·Journal of Clinical Pathology·C A MakinW F Bodmer

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Citations

Mar 19, 2009·Thyroid : Official Journal of the American Thyroid Association·Rachel DesailloudDidier Hober
Oct 1, 1996·The Journal of Pathology·D Wynford-Thomas
Jun 4, 2010·Pharmaceuticals·Mark C BagleyDavid Kipling
May 26, 1999·The Journal of Pathology·D Wynford-Thomas
Mar 1, 1995·Molecular Carcinogenesis·D Wynford-ThomasC J Jones
Mar 25, 2016·PloS One·Agnieszka Anna CzajkaKrystian Jażdżewski
Aug 1, 1997·The Journal of Clinical Endocrinology and Metabolism·M IvanD Wynford-Thomas
Apr 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D Wynford-Thomas

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