Direct hypothalamic and indirect trans-pallidal, trans-thalamic, or trans-septal control of accumbens signaling and their roles in food intake

Frontiers in Systems Neuroscience
Kevin R Urstadt, B Glenn Stanley

Abstract

Due in part to the increasing incidence of obesity in developed nations, recent research aims to elucidate neural circuits that motivate humans to overeat. Earlier research has described how the nucleus accumbens shell (AcbSh) motivates organisms to feed by activating neuronal populations in the lateral hypothalamus (LH). However, more recent research suggests that the LH may in turn communicate with the AcbSh, both directly and indirectly, to re-tune the motivation to consume foods with homeostatic and food-related sensory signals. Here, we discuss the functional and anatomical evidence for an LH to AcbSh connection and its role in eating behaviors. The LH appears to modulate Acb activity directly, using neurotransmitters such as hypocretin/orexin or melanin concentrating hormone (MCH). The LH also indirectly regulates AcbSh activity through certain subcortical "relay" regions, such as the lateral septum (LS), ventral pallidum (VP), and paraventricular thalamus, using a variety of neurotransmitters. This review aims to summarize studies on these topics and outline a model by which LH circuits processing energy balance can modulate AcbSh neural activity to regulate feeding behavior.

References

Jan 1, 1992·Neuroscience and Biobehavioral Reviews·G J Schaefer, R P Michael
May 8, 1992·The Journal of Comparative Neurology·J C BittencourtP E Sawchenko
Jan 1, 1991·Experimental Brain Research·P ApicellaW Schultz
Jul 15, 1986·The Journal of Comparative Neurology·J H Fallon, F M Leslie
Dec 1, 1988·Pharmacology, Biochemistry, and Behavior·B G StanleyS F Leibowitz
Apr 8, 1987·The Journal of Comparative Neurology·R E HarlanD W Pfaff
Jun 1, 1986·Behavioral Neuroscience·F W FlynnJ C Mitchell
Aug 1, 1985·Neuroscience·B M ChronwallT L O'Donohue
May 15, 1985·The Journal of Comparative Neurology·S N HaberW J Nauta
Oct 1, 1985·Neuroscience·O T Phillipson, A C Griffiths
Feb 1, 1971·Physiology & Behavior·J L Altman, T B Wishart
Sep 5, 1983·Life Sciences·N Johnson, G W Pasternak
Aug 21, 1995·The Journal of Comparative Neurology·M M MogaR Y Moore
Dec 15, 1994·Biochemical and Biophysical Research Communications·S R GeorgeB F O'Dowd
Nov 12, 1993·Neuroscience Letters·M MinamiM Satoh
Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·E PotterW Vale

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Citations

Oct 8, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Montserrat NavarroTodd E Thiele
May 25, 2016·Molecular Psychiatry·F H Do MonteM A Penzo
Jul 10, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shani GendelisYonatan M Kupchik
Jul 29, 2021·Brain Structure & Function·Müzeyyen UgurDominique Massotte

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Methods Mentioned

BETA
light microscopy
electron microscopy

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