Direct Immunofluorescence as a Helpful Tool for the Differential Diagnosis of Oral Lichen Planus and Oral Lichenoid Lesions

The American Journal of Dermatopathology
Yasmin YamanakaAna Carolina Motta

Abstract

A great number of lichenoid lesions have overlapping clinicopathological features, so the use of adjunct tests to establish definitive diagnosis is recommended for correct management and prognosis of the lesions. In this context, direct immunofluorescence (DIF) can be a useful tool. Thus, this study aimed to characterize the clinical, histopathological, and DIF pattern in patients with oral lichen planus (OLP) and patients with oral lichenoid lesions (OLLs). Patients with OLP and patients with OLL were characterized and compared with patients with mucous membrane pemphigoid, pemphigus vulgaris, and fibrous hyperplasia through a cross-sectional study. Patients with OLP (n = 30) and patients with OLL (n = 26) were mostly white women in the fifth decade of age, with reticular lesions mainly on the buccal mucosa. All patients with OLP and half of the patients with OLL showed liquefaction degeneration at the basal cell layer and a band-like lymphocytic infiltrate in the subepithelial tissue. Twenty-two patients with OLP (73.3%), 10 with OLL (38.4%), 25 with mucous membrane pemphigoid (96.1%), and all with pemphigus vulgaris (100%) had positive DIF. There was no positive DIF in patients with fibrous hyperplasia. The most frequent DIF...Continue Reading

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Citations

Aug 14, 2020·Oral Diseases·Mayara Sayuri Kamimura AkamaAna Carolina Fragoso Motta
Feb 1, 2019·Head and Neck Pathology·Sarah G FitzpatrickAshley N Clark
Jul 18, 2019·Frontiers in Immunology·Franziska HübnerAndreas Recke
Apr 17, 2019·Clinical Oral Investigations·Miriane Lucindo ZucolotoAna Carolina Fragoso Motta
Jun 8, 2021·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Farzan SolimaniKatharina Meier

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