Direct infusion MS-based lipid profiling reveals the pharmacological effects of compound K-reinforced ginsenosides in high-fat diet induced obese mice

Journal of Agricultural and Food Chemistry
Jong Cheol ShonKwang-Hyeon Liu

Abstract

The serum lipid metabolites of lean and obese mice fed normal or high-fat diets were analyzed via direct infusion nanoelectrospray-ion trap mass spectrometry followed by multivariate analysis. In addition, lipidomic biomarkers responsible for the pharmacological effects of compound K-reinforced ginsenosides (CK), thus the CK fraction, were evaluated in mice fed high-fat diets. The obese and lean groups were clearly discriminated upon principal component analysis (PCA) and partial least-squares discriminant analysis (PLS-DA) score plot, and the major metabolites contributing to such discrimination were triglycerides (TGs), cholesteryl esters (CEs), phosphatidylcholines (PCs), and lysophosphatidylcholines (LPCs). TGs with high total carbon number (>50) and low total carbon number (<50) were negatively and positively associated with high-fat diet induced obesity in mice, respectively. When the CK fraction was fed to obese mice that consumed a high-fat diet, the levels of certain lipids including LPCs and CEs became similar to those of mice fed a normal diet. Such metabolic markers can be used to better understand obesity and related diseases induced by a hyperlipidic diet. Furthermore, changes in the levels of such metabolites can...Continue Reading

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Citations

Sep 24, 2015·Journal of Separation Science·Li YangHuwei Liu
Jul 16, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Minéia WeberDolors Serra
Feb 21, 2018·Phytochemical Analysis : PCA·Wei WuShuying Liu
Mar 23, 2018·The Journal of Endocrinology·Jung-Yoon HeoSo-Young Park
Apr 22, 2020·Journal of Enzyme Inhibition and Medicinal Chemistry·Yoojin SongYoung Ho Seo
Dec 9, 2016·The Journal of Nutritional Biochemistry·Longyun ZhangHongwei Si

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