PMID: 47535Apr 19, 1975Paper

Direct inhibition of gastric acid by growth-hormone release-inhibiting hormone in dogs

Lancet
A A Barros D'saJ H Baron

Abstract

To find out if growth-hormone release-inhibiting hormone (G.H.-R.I.H.) had any direct action on gastric acid production independent of its effect on gastrin release, cyclic G.H.-R.I.H. was infused at a rate of 20 mug. per kg. per hour into dogs with gastric fistulae. Gastric acid output fell sharply in response to three stimuli acid production--a meal and pentagastrin and histamine infusions. The fact that acid output was inhibited during pentagastrin administration suggests that G.H.-R.I.H. has a direct action on the gastric parietal cell.

Citations

Jan 14, 1978·Diabetologia·R LuftT Hökfelt
Nov 1, 1977·The American Journal of Digestive Diseases·S J KonturekZ Wierzbicki
Jan 1, 1981·The Japanese Journal of Surgery·S NomiyamaS Majima
Jan 1, 1980·Acta diabetologica latina·S ItoY Matsubara
Jan 1, 1976·European Journal of Pharmacology·M Korner, A Ramu
Dec 23, 1985·Life Sciences·K N Dileepan, S R Wagle
Dec 1, 1980·Regulatory Peptides·W E Thomas
Sep 7, 2000·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A PezzoliS Gullini
May 8, 1975·The New England Journal of Medicine·C J Goodner
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Jan 1, 1976·Clinical Endocrinology·J M PolakA G Pearse
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Jul 1, 1976·The Journal of Clinical Investigation·S J KonturekA V Schally

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