PMID: 9531368Apr 8, 1998Paper

Direct injection of 90Y MoAbs into glioma tumor resection cavities leads to limited diffusion of the radioimmunoconjugates into normal brain parenchyma: a model to estimate absorbed radiation dose

International Journal of Radiation Oncology, Biology, Physics
K I HopkinsJ T Kemshead

Abstract

Previously we have demonstrated that radioimmunoconjugates can be injected into glioma resection cavities to deliver a boost of radiation to the cavity edge with little toxicity to the normal brain. In the mathematical models we have previously published to assist in the development of this strategy we assumed that antibody remains associated with the cavity edge and no diffusion occurs. However, moderate diffusion might be beneficial while, if this were excessive, it would decrease the therapeutic index markedly. Selected individuals with relapsed malignant glioma underwent further surgical debulking; 90Y MoAb radioimmunotherapy; and open biopsy to determine the extent to which the conjugate diffuses from the cavity edge. Samples from these patients were taken in radial tracts and the corrected activity in each sample was plotted against distance from the cavity wall to determine appropriate diffusion constants. Our data indicates that diffusion of radioimmunoconjugate from the edge of a glioma resection cavity appears to be an exponential process. The mean Ro for each patients data set ranged from 0.48-0.63 (overall mean 0.6) cm. A dosimetric model was developed that translates these measurements into estimates of radiation d...Continue Reading

References

Oct 1, 1979·International Journal of Radiation Oncology, Biology, Physics·M D WalkerG E Sheline
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·C O ScharfenK R Lamborn
Feb 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·K HopkinsJ T Kemshead

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Citations

May 4, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Francesca BottaGiovanni Paganelli
Dec 21, 2000·Current Oncology Reports·J J Olson
Dec 17, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Maximilian NiyaziClaus Belka
Oct 24, 2007·Cancer Letters·Markus Jensen, Frank Berthold
Apr 9, 2005·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Barbara Gonzalez NavarroRolando Perez
Mar 6, 2007·Expert Opinion on Drug Delivery·Adam N Mamelak, Douglas B Jacoby
Mar 21, 2007·Expert Opinion on Investigational Drugs·David E Gerber, John Laterra
May 12, 2007·Expert Review of Anticancer Therapy·David A ReardonDarell D Bigner
Apr 15, 2004·British Journal of Cancer·M R Zalutsky
Dec 24, 2019·Nuclear Medicine and Molecular Imaging·Ali GholamrezanezhadMajid Assadi
Jul 22, 2017·Molecular Cancer Therapeutics·Ela MarkovskyRonit Satchi-Fainaro
Jul 3, 2021·Molecular Medicine Reports·Yuchen SunJian Liu

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