Direct innervation of the Drosophila melanogaster larval aorta

Brain Research
Andrew F M Johnstone, Robin L Cooper

Abstract

The heart rate of larval Drosophila is modulated by various biogenic amines and peptides. The actions have always been assumed to be due to direct action on the heart since the larval heart was not known to be innervated. A recent study showed a difference in the sensitivity of the larval heart to serotonin when the CNS was ablated, thus suggesting a direct neural input. Here, we show that GFP tagged motor neurons and nerve terminals are present on the aortic region of the heart. Motor neuron cell bodies also exist outside the CNS. Transmission electron microscopy reveals the direct innervation in the aortic tissue. Thus, developmental and regulatory questions in this genetic model can now be addressed in relation to heart development and neural control.

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Citations

Mar 23, 2007·Genes, Brain, and Behavior·W S NeckameyerS F Goodwin
Oct 7, 2015·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Cole A MalloyRobin L Cooper
Feb 20, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Kevin M CrispXong Yang
Nov 6, 2008·Arthropod Structure & Development·Christine LehmacherAchim Paululat
May 23, 2016·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Yue Chen ZhuRobin L Cooper
Jul 26, 2007·The European Journal of Neuroscience·Sameera DasariRobin L Cooper
Jun 15, 2017·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Cole MalloyRobin L Cooper
Oct 11, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Cecilia PankauRobin L Cooper

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