Direct interaction between FcgammaRI (CD64) and periplakin controls receptor endocytosis and ligand binding capacity

Proceedings of the National Academy of Sciences of the United States of America
Jeffrey M BeekmanJeanette H W Leusen

Abstract

FcgammaRI depends for its biological function on both the intracellular domain of the alpha-chain and associated Fc receptor (FcR) gamma-chains. However, functional protein effectors of FcgammaRI's intracellular domain have not been identified. In this study, we identified periplakin (PPL) as a selective interacting protein for the intracellular tail of FcgammaRI but no other activatory FcRs. The interaction was confirmed by coimmunoprecipitation and blot-overlay assays. PPL and FcgammaRI colocalized at the plasma membrane in monocytes and cell transfectants, and both were up-regulated by IFN-gamma. By expressing C-terminal PPL in transfectants, we established a pivotal role for this protein in FcgammaRI ligand binding, endocytosis, and antigen presentation. These data illustrate that intracellular protein interactions with a multisubunit FcR alpha-chain can confer unique properties to the receptor.

References

Jul 1, 1992·Trends in Biochemical Sciences·D W Carr, J D Scott
May 1, 1991·Journal of Leukocyte Biology·J G van de Winkel, C L Anderson
May 1, 1993·Immunology Today·J G van de Winkel, P J Capel
Jan 15, 1996·The Journal of Clinical Investigation·I A HeijnenJ G van de Winkel
Oct 1, 1995·Journal of Hematotherapy·I A Heijnen, J G Van de Winkel
May 1, 1996·The Journal of Experimental Medicine·K L MillerC L Anderson
Jan 2, 1997·FEBS Letters·A StrzeleckaA Sobota
Jan 1, 1997·Annual Review of Immunology·M Daëron
Jan 22, 1998·Cancer Immunology, Immunotherapy : CII·P K WallaceM W Fanger
Feb 5, 1999·European Journal of Immunology·M J van VugtJ G van de Winkel
Dec 10, 1999·Molecular Biology of the Cell·P M Steinert, L N Marekov
Mar 13, 2001·Annual Review of Immunology·J V Ravetch, S Bolland
Feb 21, 2002·Trends in Cell Biology·Conrad L LeungRonald K H Liem
Aug 30, 2002·The Journal of Biological Chemistry·Jeffrey C EdbergRobert P Kimberly
Sep 24, 2002·Journal of Cell Science·A Pieter J van den HeuvelBoudewijn M T Burgering
Nov 15, 2002·Journal of Cell Science·Tadashi Karashima, Fiona M Watt

❮ Previous
Next ❯

Citations

Jan 19, 2011·Bone Marrow Transplantation·A van Royen-KerkhofJ H W Leusen
Aug 26, 2010·The Journal of Biological Chemistry·Christine Y Zhang, James W Booth
Oct 12, 2010·American Journal of Respiratory and Critical Care Medicine·Camille TailléBruno Crestani
Jul 16, 2013·BMC Gastroenterology·Shinji ItoFrank J Gonzalez
Jan 9, 2014·Journal of Translational Medicine·Jiebai ZhouXiangdong Wang
Aug 1, 2012·Cellular and Molecular Life Sciences : CMLS·Kristi BakerRichard S Blumberg
Jan 17, 2016·Annual Review of Immunology·David A RhodesJohn Trowsdale
Mar 9, 2018·JCI Insight·Valérie BesnardBruno Crestani
Apr 23, 2010·European Journal of Immunology·Jantine E BakemaJeanette H W Leusen
Dec 6, 2018·Molecular Biology of the Cell·Mansi GujratiRam Kumar Mishra
Aug 21, 2009·Parasite Immunology·R J Pleass
Jul 6, 2007·FEMS Immunology and Medical Microbiology·Melanie WellingtonConstantine G Haidaris
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Benjamin M DaleSteven Greenberg
Oct 27, 2015·Immunological Reviews·Arianne M BrandsmaJeanette H W Leusen
Oct 27, 2015·Immunological Reviews·Jennifer F A Swisher, Gerald M Feldman
Oct 27, 2015·Immunological Reviews·Alicia M ChenowethP Mark Hogarth
Apr 6, 2019·Frontiers in Immunology·Leo Koenderman
Aug 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marielle A OttenMarjolein van Egmond
Feb 3, 2011·Cell Biology International·John GardinerJan Marc
Jul 26, 2018·Science Signaling·Arianne M BrandsmaJeanette H W Leusen
Mar 7, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeffrey M BeekmanJeanette H W Leusen
Apr 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marielle A OttenMarjolein van Egmond
Sep 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jantine E BakemaJeanette H W Leusen
Dec 13, 2005·Clinical Science·Jianguo ShiRichard J Pleass
Jan 22, 2008·Immunology Letters·Jeffrey M BeekmanJeanette H W Leusen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.