Direct interaction of Ste11 and Mkk1/2 through Nst1 integrates high-osmolarity glycerol and pheromone pathways to the cell wall integrity MAPK pathway

FEBS Letters
Gang Leng, Kiwon Song

Abstract

Coordination and cross talks of MAPK pathways are critical for signaling efficiency, but their mechanisms are not well understood. Slt2, the MAP kinase of cell wall integrity pathway (CWI), is activated by heat stress even in the absence of upstream components of this pathway, suggesting a supplementary input for Slt2 activation. Here, we identify a new interaction of Ste11 and Mkk1, mediated by Nst1 that connects the high-osmolarity glycerol and pheromone pathways directly to CWI pathway in response to heat and pheromone. We suggest that Ser(407) and Thr(411) are novel residues of Mkk1 activated by these MAPK pathways.

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Citations

Dec 1, 2017·Proceedings of the National Academy of Sciences of the United States of America·Morgan DelarueOskar Hallatschek
Jun 2, 2018·Journal of Cell Science·Yuko SukegawaYoshikazu Ohya
Feb 18, 2020·Nucleic Acids Research·Cristina ViéitezEulàlia de Nadal
Aug 5, 2021·Molecular Biology of the Cell·Chin Leng ChengMark Hochstrasser

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