Direct Intrahepatic Portocaval Shunt for Sinusoidal Obstruction Syndrome Associated with Hepatotoxicity of Pyrrolizidine Alkaloids

BioMed Research International
Shi-Hua LuoKe-Chun Yao

Abstract

We retrospectively identified 89 consecutive patients from January 2004 to January 2012 to investigate efficacy of direct intrahepatic portocaval shunt (DIPS) combined with inferior vena cava (IVC) stenting for sinusoidal obstruction syndrome (SOS) associated with hepatotoxicity of pyrrolizidine alkaloids. Indications for treatment were variceal hemorrhage and/or refractory ascites. Patients were treated with DIPS plus IVC stenting (group A, n=68) or DIPS alone (group B, n=21). A technical success rate of 100% was obtained in all 89 patients, and there were no early procedure-related adverse events or 30-day mortality. Mean portosystemic gradient decreased in both groups. Changes in aspartate and alanine aminotransferases and total bilirubin did not differ between the groups. Ascites disappeared in group A but was not obvious in group B until IVC stenting. During follow-up, recurrent bleeding and ascites and incidence of hepatic encephalopathy did not differ between the groups. The 1-, 3-, and 5-year survival rate was 98, 89.59, and 80%, respectively. Satisfactory clinical results were obtained for combined DIPS and IVC stenting for SOS associated with pyrrolizidine-alkaloid-related decompensated cirrhosis.

References

Sep 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S I BearmanG B McDonald
Feb 15, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·P Rajvanshi, G B McDonald
Jun 16, 2001·Clinical Biochemistry·A PopatM G Neuman
Feb 14, 2004·Journal of Vascular and Interventional Radiology : JVIR·Timothy W I ClarkS William Stavropoulos
Apr 28, 2007·World Journal of Gastroenterology : WJG·Ulas-Darda BayraktarYusuf Bayraktar
Aug 1, 2007·World Journal of Gastroenterology : WJG·M SenzoloA-K Burroughs
Apr 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Laurie D DeLeveUNKNOWN American Association for the Study Liver Diseases
Nov 11, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Thomas D BoyerUNKNOWN American Association for the Study of Liver Diseases
Jun 25, 2010·The New England Journal of Medicine·Juan Carlos García-PagánUNKNOWN Early TIPS (Transjugular Intrahepatic Portosystemic Shunt) Cooperative Study Group
Jun 10, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Isabel Campos-VarelaRamón Charco
Jun 29, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Enric CarrerasMontserrat Rovira
Sep 21, 2011·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·G PuhlP Neuhaus
Feb 4, 2012·Journal of Hepatology·Aurélie PlessierDominique-Charles Valla
Jan 11, 2013·Journal of Zhejiang University. Science. B·Xia-zhen YuTing-bo Liang
Sep 12, 2013·Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques·Reem J Abdualmjid, Consolato Sergi
Oct 10, 2013·British Journal of Haematology·Fiona L DignanUNKNOWN British Society for Blood and Marrow Transplantation
Nov 22, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Xingshun QiGuohong Han
Mar 13, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pierre BerliouxChristophe Bureau
Jan 16, 2015·European Journal of Gastroenterology & Hepatology·Andrea Mancuso
Mar 11, 2015·Journal of Clinical and Experimental Hepatology·Cathy Q Fan, James M Crawford
Apr 4, 2016·Clinics and Research in Hepatology and Gastroenterology·Dominique-Charles Valla, Dominique Cazals-Hatem

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.