Direct Involvement of Arachidonic Acid in the Development of Ear Edema via TRPV3

Journal of Oleo Science
Takao SanakiYasuyuki Igarashi

Abstract

Arachidonic acid (AA) plays a pivotal role in the development of edema via its oxidized metabolites derived from cyclooxygenase (COX) and lipoxygenase (LOX), and is recently recognized as an activator of TRPV3. However, it is not clear whether AA plays some TRPV3-mediated pathological roles in the development of edema. Pharmacological and histological studies using ICR(TRPV3+/+) and ICR(TRPV3-/-) mice indicated that higher ear edema responses to topical application of AA were observed in ICR(TRPV3+/+) mice compared with ICR(TRPV3-/-) mice. However, there was no difference in the ear edema response to 12-O-tetradecanoylphorbol 13-acetate, skin histology, and skin barrier function between these mouse strains. Furthermore, oxidized fatty acids from the lesional site were analyzed to elucidate the TRPV3-mediated pathological roles of AA, and the results revealed that there were no differences in the level of COX or LOX metabolites derived from AA between both mouse strains. We concluded that AA plays a role in the development of TRPV3-mediated ear edema and that this result may contribute to better understanding of the pathophysiological mechanisms involved in the development of a certain type of edema.

References

Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J E NiedelG R Vandenbark
Mar 15, 2002·Cell·Andrea M PeierArdem Patapoutian
May 23, 2002·Science·Andrea M PeierArdem Patapoutian
Jun 22, 2002·Nature·Haoxing XuDavid E Clapham
Jun 4, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Man-Kyo ChungMichael J Caterina
Mar 25, 2006·Journal of Cellular Physiology·Hong-Zhen HuMichael X Zhu
Jul 22, 2006·The Journal of Investigative Dermatology·Makoto AsakawaTsuneaki Sakata
Mar 16, 2007·The British Journal of Dermatology·T AmanoT Tamura
Aug 30, 2008·The Journal of Investigative Dermatology·Takeshi YoshiokaAkinori Arimura
Dec 19, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Susan M HuangMichael J Caterina
May 26, 2009·Journal of Inflammation·Kinichi ImuraTsuneaki Sakata
Jan 16, 2010·Nature Reviews. Cancer·Jamie I FletcherMurray D Norris
Apr 17, 2010·The Journal of Biological Chemistry·Sangsu BangSun Wook Hwang
Nov 6, 2010·Archives of Pharmacal Research·Sangsu BangSun Wook Hwang
Apr 6, 2012·The Journal of Investigative Dermatology·Erika Yamamoto-KasaiTakeshi Yoshioka
Jul 10, 2013·The Journal of Physiology·Bernd NiliusGrzegorz Owsianik
Oct 30, 2013·Experimental Dermatology·Erika Yamamoto-KasaiTakeshi Yoshioka
Jan 28, 2014·The Journal of Investigative Dermatology·Ori EytanEli Sprecher
Oct 30, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Reona AijimaMizuho A Kido
Feb 11, 2015·The Journal of Investigative Dermatology·Alexandra C KendallAnna Nicolaou
Apr 19, 2015·Orphanet Journal of Rare Diseases·Sabine Duchatelet, Alain Hovnanian
Feb 13, 2016·Rapid Communications in Mass Spectrometry : RCM·Takao SanakiYoshito Numata
Dec 28, 2016·Journal of Dermatological Science·Masato WakabayashiAkio Kihara

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Citations

Oct 23, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Takao SanakiAkihiko Sato
Aug 28, 2021·International Journal of Molecular Sciences·Paola Bustos-SalgadoMaría Luisa Garduño-Ramírez

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