Direct ionization of biological tissue for mass spectrometric analysis

The Analyst
Bin HuZhong-Ping Yao

Abstract

Analysis of biological tissue at a molecular level is of great importance in biological, medical and clinical studies. In this manuscript, we report that both plant and animal tissues can be directly ionized and analyzed by mass spectrometry under ambient conditions. By adding some solvents and applying a high voltage, spray ionization can be induced at the tip of biological tissue and a mass spectrum can be observed. Various plant and animal tissues have been tested and compounds such as lipids, alkaloids, glucosides, lignans, pharmaceuticals and proteins could be detected in the spectra. This new technique provides a simple and rapid method for tissue analysis and allows observation of compounds that cannot be detected by other ionization techniques.

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Citations

Dec 15, 2012·Journal of the American Society for Mass Spectrometry·Bin HuZhong-Ping Yao
Jul 31, 2013·Journal of the American Society for Mass Spectrometry·Zhan YuKenzo Hiraoka
Oct 10, 2013·Journal of the American Society for Mass Spectrometry·Yunyun YangZhong-Ping Yao
Jan 15, 2014·Analytica Chimica Acta·Haixing WangZhong-Ping Yao
Jan 16, 2014·Bioanalysis·Cheng-Huang LinTing-Yang Kuo
Feb 1, 2013·Molecular BioSystems·Pui-Kin SoZhong-Ping Yao
Feb 27, 2016·Bioanalysis·Nicholas E ManickeChengsen Zhang
Dec 15, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Melody Yee-Man WongZhong-Ping Yao
Oct 17, 2015·Journal of Pharmaceutical and Biomedical Analysis·Gui-Zhong XinLi-Fang Liu
Jul 8, 2015·Journal of Mass Spectrometry : JMS·Gabriela PetroselliRosa Erra-Balsells
Aug 19, 2015·Analytical and Bioanalytical Chemistry·Alexey KononikhinEugene Nikolaev
Sep 9, 2015·Analytica Chimica Acta·Christian W Klampfl, Markus Himmelsbach
Mar 7, 2014·Analytica Chimica Acta·Bin HuZhong-Ping Yao
Apr 26, 2016·Analytical Chemistry·Baocheng JiYan Zhou
Sep 14, 2016·Analytica Chimica Acta·Ho-Yi WongZhong-Ping Yao
Oct 11, 2016·Journal of Mass Spectrometry : JMS·Bi-Cheng YangOu-Ping Huang
Oct 28, 2019·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Lin WuBin Hu
Jan 1, 2014·Mass Spectrometry·Pui-Kin SoZhong-Ping Yao
Aug 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gennady SukhikhVladimir Frankevich

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