Direct Lineage Reprogramming for Brain Repair: Breakthroughs and Challenges

Trends in Molecular Medicine
Rory VignolesChristophe Heinrich

Abstract

Injury to the human central nervous system (CNS) is devastating because our adult mammalian brain lacks intrinsic regenerative capacity to replace lost neurons and induce functional recovery. An emerging approach towards brain repair is to instruct fate conversion of brain-resident non-neuronal cells into induced neurons (iNs) by direct lineage reprogramming. Considerable progress has been made in converting various source cell types of mouse and human origin into clinically relevant iNs. Recent achievements using transcriptomics and epigenetics have shed light on the molecular mechanisms underpinning neuronal reprogramming, while the potential capability of iNs in promoting functional recovery in pathological contexts has started to be evaluated. Although future challenges need to be overcome before clinical translation, lineage reprogramming holds promise for effective cell-replacement therapy in regenerative medicine.

References

Mar 16, 2002·Nature Neuroscience·Nico HeinsMagdalena Götz
Sep 2, 2003·Neuron·Victoria GrahamLarysa Pevny
Dec 7, 2005·Proceedings of the National Academy of Sciences of the United States of America·Annalisa BuffoMagdalena Götz
Nov 17, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yasuo OhoriMasato Nakafuku
Jul 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Goichi MiyoshiGord Fishell
Aug 10, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benedikt BerningerMagdalena Götz
Dec 23, 2008·Nature Biotechnology·Kevin D FoustBrian K Kaspar
May 27, 2010·PLoS Biology·Christophe HeinrichBenedikt Berninger
Jun 22, 2010·Cerebral Cortex·Robert BlumMagdalena Götz
Oct 19, 2010·Nature Neuroscience·Caroline Rouaux, Paola Arlotta
Jan 21, 2011·Nature Reviews. Neuroscience·Stefanie RobelMagdalena Götz
Feb 5, 2011·Nature Protocols·Christophe HeinrichBenedikt Berninger
Oct 15, 2011·Nature Biotechnology·Thomas Vierbuchen, Marius Wernig
Dec 6, 2011·Cell Stem Cell·Nan YangMarius Wernig
Dec 12, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yuhua WangLeaf Huang
Jan 8, 2013·Nature Neuroscience·Andres De la RossaDenis Jabaudon
Jan 22, 2013·Nature Cell Biology·Caroline Rouaux, Paola Arlotta
Mar 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Olof TorperMalin Parmar
Aug 27, 2013·Nature Communications·Andrew GrandeMasato Nakafuku
Sep 24, 2013·Nature Cell Biology·Wenze NiuChun-Li Zhang
Feb 1, 2014·Science·Ryoji Amamoto, Paola Arlotta
Feb 27, 2014·Nature Communications·Zhida SuChun-Li Zhang
Jul 6, 2014·Physiological Reviews·Leda Dimou, Magdalena Götz
Dec 3, 2014·Stem Cell Reports·Christophe HeinrichMagdalena Götz
Apr 30, 2015·Stem Cell Reports·Wenze NiuChun-Li Zhang
May 17, 2017·Stem Cell Reports·Rebecca BruletJenny Hsieh
Jun 13, 2017·Stem Cell Reports·Malek ChouchaneMarcos Romualdo Costa

❮ Previous
Next ❯

Citations

May 30, 2020·Journal of Molecular Cell Biology·Cheng Qian, Feng-Quan Zhou
Nov 11, 2020·Neurobiology of Disease·Stefan H Stricker, Magdalena Götz
Nov 14, 2020·Cells·Jessica GiacomoniDaniella Rylander Ottosson
Aug 2, 2021·Current Opinion in Genetics & Development·Sven FalkMarisa Karow

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.