Direct measurement of free copper in serum or plasma ultrafiltrate

American Journal of Clinical Pathology
Gwendolyn A McMillinJohn W Hunt

Abstract

Copper is an essential element and, under conditions of overload, a toxicant. A dramatic example of copper toxicity is Wilson disease (WD), a treatable but often fatal condition that is difficult to diagnose and monitor. A method for direct measurement of free copper concentrations in serum or plasma ultrafiltrate by inductively coupled mass spectrometry was developed and validated to assist with diagnosis and monitoring WD. The method was shown to be accurate (94%-109% recoveries), linear (0.5-800 microg/dL [0.08-126 micromol/L]), and precise (coefficient of variation, < 15% over the analytic measurement range). A reference interval (0-10 microg/dL [0-1.6 micromol/L]) was determined parametrically with 137 healthy adult (20-59 years) blood donors. No statistically significant difference was observed in males (n = 69) vs females (n = 68). Free copper concentrations for patients diagnosed with WD were at least 6-fold greater than the upper limit of the reference interval before treatment but fell within the reference interval after treatment.

References

Mar 1, 1995·Journal of Hepatology·G FaaG Crisponi
Feb 1, 1995·Pediatric Research·H OgiharaM Mino
Oct 1, 1994·American Journal of Clinical Pathology·J LudwigJ Rakela
Jul 15, 1999·Journal of Clinical Gastroenterology·S A Pfeil, D J Lynn
Jun 5, 2002·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·V E KaganJ M Roberts
Aug 16, 2002·Free Radical Research·Ulf A NilssonIngemar Kjellmer
Jun 15, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Denise BohrerSolange Cristina G Pomblum
Jun 19, 2004·Virchows Archiv : an International Journal of Pathology·Cord Langner, Helmut Denk
Dec 23, 2004·The Journal of Laboratory and Clinical Medicine·Georgina MacintyreDiane W Cox
Apr 28, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Claudio BabiloniPaolo M Rossini
Jul 21, 2007·Journal of Neural Transmission·R SquittiP M Rossini

❮ Previous
Next ❯

Citations

May 23, 2014·Expert Reviews in Molecular Medicine·Alexandra Grubman, Anthony R White
May 8, 2009·Analytical and Bioanalytical Chemistry·Souleiman El BalkhiFrance Woimant
Aug 19, 2010·International Journal of Molecular Sciences·Jesse BertinatoLouise J Plouffe
May 17, 2011·Biological Trace Element Research·Mohammad Hossein DabbaghmaneshGholamhossein Ranjbar Omrani
Aug 17, 2010·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·George J Brewer
Sep 2, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Shilpa SharmaAbhimanew Dhir
Nov 18, 2011·Molecular Biology International·Isidoros IakovidisStylianos M Piperakis
Sep 27, 2015·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Aliakbar HedayatiSeyed Hossein Hoseinifar
Apr 15, 2015·Biological Trace Element Research·Lihong XinFaming Pan
Oct 22, 2013·Nitric Oxide : Biology and Chemistry·Christian OpländerChristoph V Suschek
Feb 2, 2010·The Biochemical Journal·Chris TselepisDouglas G Ward
May 24, 2015·The Journal of Nutritional Biochemistry·Francesco PiacenzaEugenio Mocchegiani
Jan 31, 2015·Biochemical and Biophysical Research Communications·Ji-Wei ZhangXun-Hua Li
Sep 1, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Souleiman El BalkhiFrance Woimant
Nov 21, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Federica BragaMauro Panteghini
Nov 7, 2015·Luminescence : the Journal of Biological and Chemical Luminescence·B RezaeiAli A Ensafi
Sep 7, 2016·Laboratory Medicine·F Bernhard KrausBeatrice Ludwig-Kraus
Jan 12, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Rosanna SquittiNicola A Colabufo
Oct 28, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Lan-Chi KönigsbergerPeter M May
Mar 6, 2018·Journal of Alzheimer's Disease : JAD·Roberta GhidoniLuisa Benussi
Apr 12, 2018·Journal of Toxicology and Environmental Health. Part a·Molly E HarmonMelissa Gonzales
Feb 17, 2018·Postgraduate Medical Journal·Claire Kelly, Marinos Pericleous
Feb 18, 2016·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Kanokwan KulprachakarnSukhvinder S Bansal
Aug 4, 2018·International Journal of Molecular Sciences·Ioana M AbbasMichael G Weller
Aug 9, 2016·Continuum : Lifelong Learning in Neurology·Ronald F Pfeiffer
Aug 14, 2020·Metallomics : Integrated Biometal Science·C Derrick QuarlesM Paul Field
Oct 16, 2016·Annals of Clinical Biochemistry·Andrew DuncanDavid Bullock
May 10, 2013·The Journal of Biological Chemistry·Edward B MaryonJack H Kaplan
Feb 8, 2020·Free Radical Biology & Medicine·Kelly C Falls-HubertDouglas R Spitz
May 4, 2021·Biological Trace Element Research·Farah AfrinLuqman A Khan
Jun 26, 2021·Pharmacology & Therapeutics·Brandán PedreTobias P Dick
Jun 30, 2021·Proceedings of the National Academy of Sciences of the United States of America·Emanuela ColomboCinthia Farina
Jul 18, 2021·Analytical and Bioanalytical Chemistry·M Estela Del Castillo BustoHeidi Goenaga-Infante
Sep 20, 2017·Chemical Research in Toxicology·Ke BianDeyu Li
Dec 21, 2019·Inorganic Chemistry·Michèle ClercGilles Gasser

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
E A RobertsAmerican Association for Study of Liver Diseases (AASLD)
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
P FerenciOskar Lorenz
© 2021 Meta ULC. All rights reserved