PMID: 3745017Jan 1, 1986Paper

Direct measurement of longitudinal endolymph flow rate in the guinea pig cochlea

Hearing Research
A N SaltB A Bohne

Abstract

The rate of longitudinal endolymph flow in the guinea pig cochlea has been measured with a novel tracer technique. The tracer we utilized was the tetramethylammonium (TMA) ion, the movement of which was monitored by ion-sensitive microelectrodes. Extremely small amounts of tracer were required as the electrodes could readily detect TMA concentrations in endolymph as low as 10 microM. TMA was introduced into scala media in the form of a small bolus, varying from 2-20 nl in volume. To examine whether longitudinal flow affects the dispersion of TMA in endolymph, we compared the characteristics of TMA spread to turn I following injection into turn II, with those of TMA spread to turn II following injection into turn I. The comparison of these data with an analytical model combining the processes of diffusion and volume flow demonstrates that the spread of tracer is dominated by passive diffusion processes with very little contribution from longitudinal endolymph flow. The rate of longitudinal endolymph flow between turn I and turn II was estimated to be less than 0.01 mm/min directed towards the basal turn. This value is considerably lower than recently published estimates using other techniques.

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Citations

Dec 23, 2006·HNO·S Plontke
Sep 11, 2004·Journal of the Association for Research in Otolaryngology : JARO·Alec N Salt
Jul 1, 1991·Journal of Neuroscience Methods·A N Salt, A Vora
Sep 15, 1988·Hearing Research·K OhyamaR Thalmann
Nov 1, 1992·Hearing Research·I ThalmannR Thalmann
Mar 31, 2009·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·John S Phillips, Peter R Prinsley
Jun 6, 2003·Brain Research Bulletin·Yehoash Raphael, Richard A Altschuler
Sep 24, 1998·Hearing Research·A N Salt, J E DeMott
Jun 1, 1995·The Laryngoscope·S W YeoE M Keithley
Apr 14, 2006·Expert Opinion on Drug Safety·Joshua G YorgasonFederico Kalinec
Jun 27, 2012·Molecular Aspects of Medicine·Andreas EckhardHubert Löwenheim
Nov 9, 2001·Annual Review of Genetics·C PetitJ P Hardelin
Oct 11, 2005·Drug Discovery Today·Alec N Salt, Stefan K R Plontke
Mar 25, 2015·Human Molecular Genetics·Takashi IizukaKatsuhisa Ikeda
Mar 17, 2015·American Journal of Otolaryngology·Hermann SimoReginald Baugh
Aug 27, 1999·The Journal of the Acoustical Society of America·A N Salt, J E DeMott
Nov 1, 1989·American Journal of Otolaryngology·A N SaltA Vora
May 1, 1991·The Annals of Otology, Rhinology, and Laryngology·K S Lee, R S Kimura
Apr 19, 2017·Journal of Audiology & Otology·Woo Seok KangJong Woo Chung
Nov 1, 1995·The Annals of Otology, Rhinology, and Laryngology·E M KeithleyM J Ruckenstein
Jul 1, 1989·The Annals of Otology, Rhinology, and Laryngology·E M OshiroH S Lusted
Jan 1, 1991·The Annals of Otology, Rhinology, and Laryngology·N MoriS Sakai
Sep 21, 2004·Current Opinion in Otolaryngology & Head and Neck Surgery·James C Andrews
Feb 9, 2005·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Saumil N MerchantJoseph B Nadol
Jun 4, 2008·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Raphaël Maire, Guy van Melle
Jan 1, 1994·Acta Oto-laryngologica. Supplementum·K GyoN Yanagihara
Mar 25, 2015·Journal of the Association for Research in Otolaryngology : JARO·A N SaltJ J Hartsock
Jun 9, 2016·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Joseph B Nadol
Nov 22, 2011·The Annals of Otology, Rhinology, and Laryngology·Jeremy HornibrookJohn Gourley
Mar 25, 2008·The Annals of Otology, Rhinology, and Laryngology·Vincent CouloignerEvelyne Ferrary
Jun 20, 2019·Frontiers in Cellular Neuroscience·Fabrice Piu, Kathie M Bishop

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