Direct measurement of molecular mobility and crystallisation of amorphous pharmaceuticals using terahertz spectroscopy

Advanced Drug Delivery Reviews
Juraj Sibik, J Axel Zeitler

Abstract

Despite much effort in the area, no comprehensive understanding of the formation and behaviour of amorphous solids has yet been achieved. This severely limits the industrial application of such materials, including drug delivery where, in principle, amorphous solids have demonstrated their great usefulness in increasing the bioavailability of poorly aqueous soluble active pharmaceutical ingredients. Terahertz time-domain spectroscopy is a relatively novel analytical technique that can be used to measure the fast molecular dynamics of molecules with high accuracy in a non-contact and non-destructive fashion. Over the past decade a number of applications for the characterisation of amorphous drug molecules and formulations have been developed and it has been demonstrated how this technique can be used to determine the onset and strength in molecular mobility that underpins the crystallisation of amorphous drugs. In this review we provide an overview of the history, fundamentals and future perspective of pharmaceutical applications related to the terahertz dynamics of amorphous systems.

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Citations

Jun 12, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Prince BawuahKai-Erik Peiponen
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Feb 6, 2020·Biomedical Optics Express·Zoltan VilagoshAndrew W Wood
Sep 1, 2019·Comprehensive Reviews in Food Science and Food Safety·Leili Afsah-HejriReza J Ehsani
Jun 21, 2021·Journal of Pharmaceutical Sciences·Ryoma TanakaMakoto Otsuka
Jul 21, 2017·The Journal of Physical Chemistry. B·Quentin VielEric Dargent
Feb 6, 2018·Analytical Chemistry·Stefan SommerAlina Adams

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