Direct measurement of the isomerization barrier of the isolated retinal chromophore

Angewandte Chemie
Jonathan DilgerYoni Toker

Abstract

Isomerizations of the retinal chromophore were investigated using the IMS-IMS technique. Four different structural features of the chromophore were observed, isolated, excited collisionally, and the resulting isomer and fragment distributions were measured. By establishing the threshold activation voltages for isomerization for each of the reaction pathways, and by measuring the threshold activation voltage for fragmentation, the relative energies of the isomers as well as the energy barriers for isomerization were determined. The energy barrier for a single cis-trans isomerization is (0.64±0.05) eV, which is significantly lower than that observed for the reaction within opsin proteins.

References

Apr 26, 1990·Biochimica Et Biophysica Acta·R R Birge
Nov 4, 1993·Nature·R B BarlowJ R Tallent
Oct 14, 2000·Annual Review of Cell and Developmental Biology·J L SpudichE N Spudich
Jun 11, 2004·Biophysical Journal·Petri Ala-LaurilaAri Koskelainen
Jun 15, 2006·Analytical Chemistry·Stormy L KoenigerDavid E Clemmer
Jan 28, 2010·Angewandte Chemie·Jyoti RajputMarco Garavelli
May 18, 2010·The Journal of Physical Chemistry. B·Nicholas A PiersonDavid E Clemmer
Jun 11, 2011·Science·Dong-Gen LuoKing-Wai Yau
Sep 8, 2012·Science·Samer GozemMassimo Olivucci
Feb 5, 2013·Journal of the American Chemical Society·Nicholas A PiersonDavid E Clemmer
Oct 22, 2013·Physical Chemistry Chemical Physics : PCCP·Y TokerL H Andersen
Dec 25, 2013·Chemical Reviews·Oliver P ErnstHideki Kandori
May 3, 2014·The Journal of Chemical Physics·N J A CoughlanE J Bieske
Jul 9, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ying GuoElsa C Y Yan
Aug 16, 2015·The Journal of Physical Chemistry Letters·N J A CoughlanE J Bieske

❮ Previous
Next ❯

Citations

Jan 13, 2016·The Journal of Physical Chemistry. B·Chang Min ChoiPhilippe Dugourd
Apr 6, 2016·The Journal of Physical Chemistry. a·Lihi MusbatYoni Toker
Jun 10, 2016·Journal of the American Society for Mass Spectrometry·Neville J A CoughlanEvan J Bieske
Nov 5, 2016·The Journal of Physical Chemistry Letters·Christopher W WestJan R R Verlet
Nov 18, 2016·Physical Chemistry Chemical Physics : PCCP·Izabella CzerwinskaPhilippe Dugourd
Aug 1, 2018·Journal of the American Society for Mass Spectrometry·Lihi MusbatYoni Toker
Jul 20, 2018·Chemistry : a European Journal·Mathieu LalandeJean-Christophe Poully
Apr 25, 2018·Physical Chemistry Chemical Physics : PCCP·Chang Min ChoiFabien Chirot
Mar 16, 2019·Nature Communications·Hjalte V KieferLars H Andersen
Feb 25, 2021·Analytical Chemistry·Aurélien Le FèvreFabien Chirot
Jun 30, 2019·The Journal of Physical Chemistry. a·Iraklis Litinas, Andreas D Koutselos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.