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Direct modulation of secretory chloride channels by arachidonic and other cis unsaturated fatty acids

Proceedings of the National Academy of Sciences of the United States of America

Aug 1, 1990

T C HwangWilliam B Guggino

PMID: 1696009

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Abstract

The effect of fatty acids on Cl- channels and transepithelial Cl- secretion is investigated. Patch-clamp experiments show that arachidonic acid blocks Cl- channels in a dose-dependent manner. Kinetic analysis shows that the mean open time is decreased 10-fold with 25 microM arachidonic ...read more

Mentioned in this Paper

Myristic Acids
Cell Secretion
SPEF1 gene
Eicosatetraenoic Acids
Acids
Cell Surface Proteins
Arachidonic Acid Measurement
Arachidonic Acid
Chloride Channels
Colforsin
Paper Details
References
  • References23
  • Citations64
123
  • References23
  • Citations64
12345...

Direct modulation of secretory chloride channels by arachidonic and other cis unsaturated fatty acids

Proceedings of the National Academy of Sciences of the United States of America

Aug 1, 1990

T C HwangWilliam B Guggino

PMID: 1696009

DOI:

Abstract

The effect of fatty acids on Cl- channels and transepithelial Cl- secretion is investigated. Patch-clamp experiments show that arachidonic acid blocks Cl- channels in a dose-dependent manner. Kinetic analysis shows that the mean open time is decreased 10-fold with 25 microM arachidonic ...read more

Mentioned in this Paper

Myristic Acids
Cell Secretion
SPEF1 gene
Eicosatetraenoic Acids
Acids

Related Papers

Paper Details
References
  • References23
  • Citations64
123
  • References23
  • Citations64
12345...

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