Direct MRI detection of neuronal magnetic fields in the brain: theoretical modeling

NeuroImage
Yiqun XueJinhu Xiong

Abstract

Whether MRI can be used for direct detection of neuronal activity is a matter of debate. Controversial theoretical and experimental results have been reported. Here, we present an improved current-dipole model to compute magnetic field generated by neural firing and to calculate MRI signal changes resulting from the neuronal magnetic field (NMF). Each dendrite or each unmyelinated axon was modeled as a modified current-dipole. NMF were estimated based on a synchronized activity of multiple neurons. Sensitivity of using phase and magnitude MRI to measure effects of NMF was evaluated. Our results show that NMF can potentially generate up to a few percent changes in MRI magnitude signals. Phases of MRI signal tend to be destructively added and are insensitive to NMF in the activated region when the distribution of the activated dendrites is symmetrical. Phases could be detected when the distribution of the activated dendrites is asymmetrical and on some neighboring voxels. Our modeling implies that direct MRI detection of neuronal activity is possible.

References

Dec 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G C ScottR M Henkelman
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K K KwongR Turner
Jun 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P A BandettiniJ S Hyde
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S OgawaK Ugurbil
Jan 1, 1989·Magnetic Resonance Imaging·M JoyM Henkelman
Nov 1, 1980·Biophysical Journal·K R Swinney, J P Wikswo
Jun 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R M WeisskoffB R Rosen
Mar 4, 1999·Journal of Magnetic Resonance·J BodurkaS J Li
Jul 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·A DarquiéD Le Bihan
Mar 9, 2002·Science·Stephen R Williams, Greg J Stuart
Jul 12, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jerzy Bodurka, Peter A Bandettini
Jun 20, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Daniel KonnRichard Bowtell
May 29, 2004·Neural Computation·Christina M WeaverW Brent Lindquist
Aug 31, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Petr VolegovRobert H Kraus
Sep 22, 2005·The Journal of Comparative Neurology·Cynthia Mills Schumann, David G Amaral

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Citations

Apr 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Nicholas W Halpern-MannersAlexander Pines
Aug 9, 2006·Proceedings of the National Academy of Sciences of the United States of America·Trong-Kha Truong, Allen W Song
Oct 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Natalia PetridouPeter A Bandettini
Jan 9, 2008·Journal of Magnetic Resonance·Trong-Kha TruongAllen W Song
Oct 16, 2007·Trends in Neurosciences·Alan Jasanoff
Oct 29, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Li Sze ChowMartyn N J Paley
May 26, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yiqun XueJinhu Xiong
Nov 9, 2007·Human Brain Mapping·Leon HellerJohn S George
Jul 27, 2007·Journal of Magnetic Resonance Imaging : JMRI·Li Sze ChowMartyn N J Paley
Jul 6, 2011·NMR in Biomedicine·Alexander J PoplawskyXiaoping P Hu
Jan 22, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Qingfei LuoJia-Hong Gao
Jul 29, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Qingfei Luo, Jia-Hong Gao
Dec 5, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xia JiangJia-Hong Gao
Oct 3, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mukund BalasubramanianDarren B Orbach
Aug 22, 2015·Interdisciplinary Sciences, Computational Life Sciences·Seyed Mehdi BagheriMofidiAli Abbaspour Tehrani-Fard
Jun 5, 2007·NeuroImage·K B BlagoevE Halgren
Nov 21, 2013·Journal of Magnetic Resonance·Rainer KörberMartin Burghoff
Sep 3, 2016·Australasian Physical & Engineering Sciences in Medicine·Seyed Mehdi BagheriMofidiAli Abbaspour Tehrani-Fard
Sep 3, 2010·Physics in Medicine and Biology·Ying-Ling HuangDe-Zhong Yao
Jan 14, 2021·Biomedical Physics & Engineering Express·Koos C J ZevenhovenRisto J Ilmoniemi

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