Direct neural current imaging in an intact cerebellum with magnetic resonance imaging

NeuroImage
Padmavathi SundaramYoshio Okada

Abstract

The ability to detect neuronal currents with high spatiotemporal resolution using magnetic resonance imaging (MRI) is important for studying human brain function in both health and disease. While significant progress has been made, we still lack evidence showing that it is possible to measure an MR signal time-locked to neuronal currents with a temporal waveform matching concurrently recorded local field potentials (LFPs). Also lacking is evidence that such MR data can be used to image current distribution in active tissue. Since these two results are lacking even in vitro, we obtained these data in an intact isolated whole cerebellum of turtle during slow neuronal activity mediated by metabotropic glutamate receptors using a gradient-echo EPI sequence (TR=100ms) at 4.7T. Our results show that it is possible (1) to reliably detect an MR phase shift time course matching that of the concurrently measured LFP evoked by stimulation of a cerebellar peduncle, (2) to detect the signal in single voxels of 0.1mm(3), (3) to determine the spatial phase map matching the magnetic field distribution predicted by the LFP map, (4) to estimate the distribution of neuronal current in the active tissue from a group-average phase map, and (5) to p...Continue Reading

References

Dec 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G C ScottR M Henkelman
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K K KwongR Turner
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S OgawaD W Tank
Oct 9, 1989·Neuroscience Letters·L J Larson-Prior, N T Slater
Jan 1, 1989·Magnetic Resonance Imaging·M JoyM Henkelman
May 1, 1988·Biophysical Journal·Y C Okada, C Nicholson
Nov 15, 1994·The Journal of Physiology·R D TraubK Tóth
Mar 4, 1999·Journal of Magnetic Resonance·J BodurkaS J Li
Oct 19, 1999·Human Brain Mapping·A M Dale
Jul 14, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G H GloverD Ress
Jul 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·A DarquiéD Le Bihan
Sep 12, 2001·Magnetic Resonance Imaging·A W Song, A M Takahashi
Jul 12, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jerzy Bodurka, Peter A Bandettini
Jun 20, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Daniel KonnRichard Bowtell
Apr 29, 2004·Nature Neuroscience·György Buzsáki
Aug 10, 2004·The Journal of Experimental Biology·Peter L Lutz, Sarah L Milton
Feb 15, 2005·Magnetic Resonance Imaging·Daniel KonnRichard Bowtell
Jul 21, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Tae Kim, Seong-Gi Kim
Apr 8, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gaby S PellGraeme D Jackson
May 9, 2006·Magnetic Resonance Imaging·Gisela E HagbergBruno Maraviglia
May 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Denis Le BihanHidenao Fukuyama
Aug 9, 2006·Proceedings of the National Academy of Sciences of the United States of America·Trong-Kha Truong, Allen W Song
Oct 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Natalia PetridouPeter A Bandettini
Jan 30, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Laura M ParkesDavid G Norris
Jun 5, 2007·NeuroImage·K B BlagoevE Halgren
Jul 27, 2007·Journal of Magnetic Resonance Imaging : JMRI·Li Sze ChowMartyn N J Paley
Nov 9, 2007·Human Brain Mapping·Leon HellerJohn S George
Nov 21, 2007·Computer Methods and Programs in Biomedicine·M StenroosJ Nenonen
Dec 1, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Giedrius T BuracasEric C Wong
Jan 9, 2008·Magnetic Resonance Imaging·Lin TangJohn C Gore

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Citations

Sep 3, 2016·Australasian Physical & Engineering Sciences in Medicine·Seyed Mehdi BagheriMofidiAli Abbaspour Tehrani-Fard
Dec 20, 2016·Scientific Reports·Francesca BarbieriGilles Ouanounou
Nov 24, 2018·Australasian Physical & Engineering Sciences in Medicine·Seyed Mehdi BagheriMofidi
Jan 18, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Trong-Kha TruongAllen W Song
Apr 12, 2019·The Keio Journal of Medicine·Seiji Ogawa, Yul-Wan Sung
Apr 9, 2020·Journal of Neural Engineering·Bragi SveinssonMatthew S Rosen
Dec 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·John F BarryRonald L Walsworth
Nov 27, 2019·Nature Methods·Jonas HandwerkerKlaus Scheffler
Oct 9, 2021·Journal of Veterinary Internal Medicine·Daniela M UngerDaniela Schweizer

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