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Direct Observation of the Formation and Dissociation of Double-Stranded DNA Containing G-Quadruplex/i-Motif Sequences in the DNA Origami Frame Using High-Speed AFM

Methods in Molecular Biology

Jan 1, 2019

Masayuki EndoHiroshi Sugiyama

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Abstract

We demonstrate the single-molecule operation and observation of the formation and resolution of double-stranded DNA (dsDNA) containing G-quadruplex (GQ)- and counterpart i-motif-forming sequences in the DNA nanostructure. Sequential manipulation of DNA strands in the DNA frame was perfo...read more

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Acids
Spatial Displacement
DNA
DNA, Single-Stranded
Microscopy, Atomic Force
DNA, Double-Stranded
Duplex
Potassium Ion
DNA Binding Domain
G-Quadruplexes
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Direct Observation of the Formation and Dissociation of Double-Stranded DNA Containing G-Quadruplex/i-Motif Sequences in the DNA Origami Frame Using High-Speed AFM

Methods in Molecular Biology

Jan 1, 2019

Masayuki EndoHiroshi Sugiyama

PMID: 31444757

DOI: 10.1007/978-1-4939-9666-7_17

Abstract

We demonstrate the single-molecule operation and observation of the formation and resolution of double-stranded DNA (dsDNA) containing G-quadruplex (GQ)- and counterpart i-motif-forming sequences in the DNA nanostructure. Sequential manipulation of DNA strands in the DNA frame was perfo...read more

Mentioned in this Paper

Acids
Spatial Displacement
DNA
DNA, Single-Stranded
Microscopy, Atomic Force

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