PMID: 2124942Oct 22, 1990Paper

Direct observations of synapses between GABA-immunoreactive boutons and muscle afferent terminals in lamina VI of the cat's spinal cord

Brain Research
D J MaxwellA G Brown

Abstract

Single group Ia muscle afferent fibres in the lumbar spinal cord of the cat were impaled with microelectrodes and labelled with horseradish peroxidase. Two collateral axons were prepared for combined light and electron microscopy. Arbors selected from lamina VI were processed by the postembedding immunogold technique with antiserum which specifically recognizes GABA in glutaraldehyde-fixed tissue. Twelve Ia boutons were examined through series of thin sections with the electron microscope and all of them were associated with presynaptic axon terminals which were positively labelled for GABA. Some Ia boutons received synaptic contacts from several GABAergic terminals. The present study establishes that a GABA-like substance is present in axon terminals presynaptic to Ia afferent boutons in lamina VI of the spinal cord. This evidence provides a morphological basis for presynaptic inhibition of Ia afferent input into lamina VI.

References

Jan 1, 1978·The Journal of Physiology·A G Brown, R E Fyffe
Mar 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P SomogyiA Erdei
Mar 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P Somogyi, A J Hodgson
Mar 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A J HodgsonP Somogyi
Nov 22, 1984·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D R Curtis, R Malik
Jan 1, 1984·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·A N van den Pol
Nov 1, 1981·British Journal of Pharmacology·K Dunlap
Apr 29, 1982·Brain Research·R P BarberE Roberts
Aug 1, 1982·Paraplegia·A Perkash, M Brown
Nov 1, 1960·The Journal of Physiology·J C ECCLESA LUNDBERG
May 1, 1962·The Journal of Physiology·J C ECCLESR F SCHMIDT
Jun 1, 1952·The Journal of Comparative Neurology·B REXED

❮ Previous
Next ❯

Citations

Jan 1, 1992·Progress in Neurobiology·E Jankowska
Dec 1, 1992·Current Opinion in Neurobiology·F ClaracD Cattaert
Nov 24, 2001·Journal of Chemical Neuroanatomy·N P VesselkinJ Repérant
Nov 26, 1999·Journal of Physiology, Paris·P Rudomin
Nov 26, 1999·Journal of Physiology, Paris·B Lamotte d'IncampsL Jami
Jun 1, 1996·Current Opinion in Neurobiology·D S McGehee, L W Role
May 21, 1999·The European Journal of Neuroscience·D J Maxwell, J S Riddell
Apr 1, 1997·The European Journal of Neuroscience·A El ManiraS Grillner
Apr 15, 1999·Annual Review of Neuroscience·A B MacDermottS A Siegelbaum
May 3, 2006·Progress in Neurobiology·William D Willis
May 26, 2017·The Journal of Comparative Neurology·Adam J SchultzFrancisco J Alvarez
Jun 18, 2003·The Journal of Comparative Neurology·Yong Chul BaeYoshio Shigenaga
Aug 5, 2003·Journal of Neuroscience Research·Jia-Hua HuLi-He Guo
Mar 17, 2005·The International Journal of Neuroscience·Shigeo TanabeYoshihisa Masakado
Jul 15, 1994·The Journal of Comparative Neurology·K A Starr, J R Wolpaw
Apr 4, 2000·Physiological Reviews·J C ReklingJ L Feldman
Feb 22, 1993·The Journal of Comparative Neurology·J ChristensonS Grillner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.