Direct Oral Anticoagulants for the Management of Thromboembolic Disorders: The Importance of Adherence and Persistence in Achieving Beneficial Outcomes

Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Alpesh Amin, Joel C Marrs

Abstract

Anticoagulation therapy is central to the management of thromboembolic disorders, and the use of direct oral anticoagulants offers several advantages over standard therapy with parenteral heparins and vitamin K antagonists. In phase III clinical trials, the direct oral anticoagulants (given once or twice daily) all demonstrated favorable benefit-risk profiles compared with conventional standard therapy for the treatment and secondary prevention of venous thromboembolism and for stroke prevention in patients with nonvalvular atrial fibrillation. In clinical practice, many factors may influence overall clinical outcomes in patients receiving anticoagulant therapy, including adherence and persistence to the prescribed therapy, which becomes particularly important during long-term therapy. When choosing an anticoagulant for an individual patient, the pharmacological and clinical profile of the anticoagulant, its dosing regimen, and the patient's clinical characteristics (eg, renal function and comorbidities) and preferences should be considered. This review examines the rationale for and clinical evidence of the selected dosing regimens of the direct oral anticoagulants for the treatment of venous thromboembolism and stroke prevent...Continue Reading

References

Sep 18, 2002·Circulation·Samuel Z Goldhaber, Ruth B Morrison
Dec 17, 2002·Heart·Chu-Pak Lau
Sep 2, 2004·Circulation·Simon J McRae, Jeffrey S Ginsberg
Mar 8, 2005·Journal of Thrombosis and Haemostasis : JTH·E PerzbornA Straub
Oct 18, 2005·British Journal of Haematology·David GarciaEdward Libby
Feb 2, 2008·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Joyce A CramerPeter K Wong
Jun 11, 2008·Journal of Thrombosis and Haemostasis : JTH·UNKNOWN Botticelli Investigators, Writing CommitteA Segers
Jan 15, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jean-Jacques ParientiEdward M Gardner
Feb 21, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Tienan ZhuJoseph Emmerich
Jun 17, 2009·Circulation·P Michael HoJohn S Rumsfeld
Sep 1, 2009·The New England Journal of Medicine·Stuart J ConnollyUNKNOWN RE-LY Steering Committee and Investigators
Sep 10, 2009·The Annals of Pharmacotherapy·Sara R VazquezMatthew T Rondina
Oct 7, 2009·Thrombosis and Haemostasis·John FanikosSamuel Z Goldhaber
Nov 3, 2009·Blood·David GarciaMark A Crowther
Nov 26, 2009·The American Journal of Cardiology·Gerald V NaccarelliKathy L Schulman
Dec 8, 2009·The New England Journal of Medicine·Sam SchulmanUNKNOWN RE-COVER Study Group
Feb 9, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Nigel S Key, Raj S Kasthuri
Apr 7, 2010·Circulation·John W Eikelboom, Jeffrey I Weitz
Apr 1, 2007·Expert Review of Pharmacoeconomics & Outcomes Research·Lizheng ShiKristina S Boye
Nov 5, 2010·The New England Journal of Medicine·Stuart J ConnollyUNKNOWN Randomized Evaluation of Long-Term Anticoagulation Therapy Investigators
Dec 7, 2010·The New England Journal of Medicine·Rupert BauersachsSebastian Schellong
Jan 26, 2011·American Journal of Hematology·S B DeitelzweigK L Schulman
Aug 13, 2011·The New England Journal of Medicine·Manesh R PatelUNKNOWN ROCKET AF Investigators
Aug 30, 2011·The New England Journal of Medicine·Christopher B GrangerUNKNOWN ARISTOTLE Committees and Investigators
Jan 12, 2012·Circulation. Cardiovascular Quality and Outcomes·Jonathan P PicciniLesley H Curtis
Mar 21, 2012·Current Medical Research and Opinion·Craig I ColemanRajbir Kaur
Mar 28, 2012·The New England Journal of Medicine·Harry R BüllerAnnelise Segers
Apr 11, 2012·British Journal of Clinical Pharmacology·Bernard VrijensUNKNOWN ABC Project Team
Apr 27, 2012·Current Medical Research and Opinion·Alexander T Cohen
Jun 16, 2012·The European Respiratory Journal·Irene M LangJason X-J Yuan

❮ Previous
Next ❯

Citations

May 14, 2016·British Journal of Haematology·John K AbdouRoopen Arya
Aug 23, 2016·Current Medical Research and Opinion·Emilio Márquez-ContrerasUNKNOWN Compliance and Inertia Working Group, Spanish Society of Hypertension (SEH-LELHA)
Jan 7, 2017·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Emilio Márquez-ContrerasUNKNOWN Working Group on Compliance and Inertia. Spanish Society of Hypertension
Jul 6, 2017·Expert Opinion on Drug Safety·José Miguel Rivera-CaravacaGregory Y H Lip
Jun 14, 2017·Wiener medizinische Wochenschrift·Christoph Sucker, Jens Litmathe
Aug 17, 2019·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Christine L BakerJay Lin
Nov 30, 2019·International Journal of Clinical Pharmacy·Jennifer Dotta-CelioLucia Mazzolai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

Revista de neurologia
Carmen Suárez-FernándezJosé Vivancos
Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Sam Schulman, Paul A Reilly
© 2021 Meta ULC. All rights reserved