Direct oral anticoagulants in oral surgery: a prospective cohort

Minerva stomatologica
Amanda Leal RochaTarcília Aparecida Silva

Abstract

Quantitative assessment of bleeding in dental extractions is rarely reported in the literature. The assessment of bleeding might provide additional evidence to predict and minimize postoperative outcomes. The aim of this study was to evaluate the pattern of bleeding in individuals taking direct oral anticoagulants (DOACs) submitted to dental extractions. Intraoperative bleeding was evaluated by using total collected bleeding corrected by absorbance reading (dental bleeding score). To monitoring bleeding episodes from the day of surgery, this cohort was followed up until the 11 seventh postoperative day. Forty-five procedures were performed in three comparative groups, patients under DOACs, individuals taking vitamin K antagonists (VKAs) and without anticoagulant therapy. No bleeding events were observed in procedures carried out in individuals of the DOAC group. Additional hemostatic measures were required in two procedures in the VKA group and one in the non-anticoagulated group. The dental bleeding scores obtained for the DOAC and VKA groups were similar. Our data suggest that the DOAC therapy did not result in increased bleeding outcomes in this sample.

References

Aug 1, 1978·Annals of the Rheumatic Diseases·W W DownieJ A Anderson
Dec 16, 1998·Journal of the American College of Surgeons·M A QuaderB E Sumpio
Feb 7, 2001·Chest·G W AlbersD E Singer
Apr 25, 2008·Journal of Hepatology·Nezam AfdhalRafael Esteban
Jan 20, 2009·Clinics in Liver Disease·Dougald M Monroe, Maureane Hoffman
Dec 8, 2009·The New England Journal of Medicine·Sam SchulmanUNKNOWN RE-COVER Study Group
Dec 7, 2010·The New England Journal of Medicine·Rupert BauersachsSebastian Schellong
Jun 7, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·James W Little
Jun 4, 2014·Australian Dental Journal·O BreikAn Goss
Jan 18, 2016·International Journal of Oral and Maxillofacial Surgery·S Johnston
Oct 22, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Cédric MauprivezVianney Descroix
Apr 22, 2017·British Dental Journal·S Nathwani, C Wanis
Nov 3, 2017·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Amanda L RochaTarcília A Silva
Apr 9, 2018·International Journal of Oral and Maxillofacial Surgery·C BensiG Lomurno
Aug 21, 2018·Clinics in Chest Medicine·Mia Djulbegovic, Alfred Ian Lee
Oct 23, 2018·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Nadia CoceroStefano Carossa
Feb 23, 2019·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Amanda Leal RochaTarcília Aparecida Silva
Apr 20, 2019·International Journal of Environmental Research and Public Health·Luigi LainoGabriele Cervino
Apr 24, 2019·Biomedicines·Luca FiorilloMarco Cicciù

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.