Direct patterning of centrosome arrays as templates for the assembly of microtubules

Biotechnology and Bioengineering
Wen ShangRichard W Siegel

Abstract

We have achieved, for the first time, the selective patterning of centrosomes onto solid substrates. The use of such patterned centrosome arrays as templates for the directed polymerization of microtubules was also demonstrated. Centrosomes are small organelles in animal cells that serve as nucleation and organization centers of microtubules. Directed assembly of microtubules on the patterned centrosome arrays provides a new route to control the positions and directions of microtubules on surfaces. Combining the patterning of the isolated centrosomes and the directed growth of microtubules may lead to the generation of desired microtubule networks for bio-based nanodevices.

References

Apr 10, 1992·Science·R E PalazzoC L Rieder
Jan 1, 1986·Methods in Enzymology·T J Mitchison, M W Kirschner
Mar 4, 1998·Current Opinion in Cell Biology·K H Downing, E Nogales
Jan 19, 1999·Methods in Cell Biology·R E Palazzo, J M Vogel
Sep 12, 2001·Methods in Cell Biology·B J Schnackenberg, R E Palazzo
Mar 6, 2003·Nature Materials·Haiqing LiuCarlo D Montemagno
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Robert J ChenHongjie Dai
Jul 28, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·Alexey A VertegelJonathan S Dordick
Jan 15, 2005·Toxicology Letters·Nancy A Monteiro-RiviereJim E Riviere
Mar 16, 1998·Angewandte Chemie·Younan Xia, George M Whitesides

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Citations

Oct 15, 2009·Analytical Biochemistry·Eduarda DráberováPavel Dráber
Jan 17, 2009·Small·Cerasela Zoica DinuJonathan S Dordick

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