Direct Photocatalytic S-H Bond Cyanation with Green "CN" Source

The Journal of Organic Chemistry
Wei GuoXiaolin Fan

Abstract

Herein we report a novel C-S bond cleavage and reconstruction strategy for the synthesis of thiocyanates through direct photocatalytic S-H bond cyanation from thiols and inorganic thiocyanate salts. In our strategy, the unprecedented example of cutting off C-S bond of SCN- to deliver the green "CN" sources is demonstrated. This transformation features nontoxic and inexpensive "CN" sources, available starting materials, metal-/base-/ligand-/peroxide-free, high step economy and mild conditions. It leads to the construction of various thiocyanates and some medicinally and biologically active thiocyanate-containing molecules.

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Citations

Jul 17, 2019·Organic & Biomolecular Chemistry·Chengqiu LiFu-Xue Chen
Mar 5, 2021·Chemical Communications : Chem Comm·Bo LuXiaoqing Zeng
Mar 17, 2021·Organic Letters·Uroš TodorovićNuno Maulide
Jun 28, 2019·The Journal of Organic Chemistry·Yang ChenZhanhui Yang
Dec 11, 2019·The Journal of Organic Chemistry·Di WuFu-Xue Chen
Jan 11, 2020·The Journal of Organic Chemistry· QumruddeenChandra Bhushan Tripathi
Sep 10, 2021·Chemical Communications : Chem Comm·Di WuFu-Xue Chen

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