Direct radioimmunoassay of human renin

The Journal of Clinical Endocrinology and Metabolism
F X GalenJ Ménard

Abstract

Antibodies were raised in rabbit against pure human renin. The antisera obtained are highly specific for human renin versus hog, dog and rat renin. They do not cross-react with acid proteases such as pepsin and human cathepsin D. A direct radioimunoassay is described for human renin in plasma and kidney extracts. 30 to 50 pg of enzyme (2.5 to 4 x 10(-5) Goldblatt units) are detected.

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Related Concepts

Kidney
Radioimmunoassay
Preprorenin

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