Direct regulation of prostate blood flow by vascular endothelial growth factor and its participation in the androgenic regulation of prostate blood flow in vivo

Endocrinology
Yasuhiro ShibataHidetoshi Yamanaka

Abstract

Previous studies on prostate blood flow regulation have indicated that androgen regulates prostate blood flow. However, the mechanism responsible for this regulation is unknown. In the present study, we focused on the effects of vascular endothelial growth factor (VEGF), a key factor responsible for angiogenesis and androgenic blood flow regulation. We examined in vivo the effect of VEGF on prostate blood flow and its participation in the androgenic regulation of this blood flow using a castrated rat model following subcapsular intraprostatic injection method. We found that VEGF is involved in blood flow regulation with an activity equal to that of dihydrotestosterone (DHT). The effect of VEGF on prostate blood flow was already seen at 30 min after the administration. The elevating effect of DHT on castrated rat prostate blood flow was abolished by coadministration of DHT with neutralizing anti-VEGF antibody. The change in VEGF-A mRNA expression in response to androgen stimulation was examined by double-fluorescent probe quantitative PCR (Taqman PCR). The results showed that androgenic regulation of VEGF gene expression occurred shortly after androgen stimulation. VEGF gene up-regulation was abolished or down-regulated by coadm...Continue Reading

References

Jul 1, 1977·Progress in Cardiovascular Diseases·M A HeymannA M Rudolph
Jan 1, 1995·Methods in Cell Biology·M C Colombel, R Buttyan
Jan 1, 1996·Current Opinion in Nephrology and Hypertension·N Ferrara, S Bunting
Oct 29, 1998·Biochemical and Biophysical Research Communications·S SordelloJ Plouët
Aug 23, 2000·Biology of Reproduction·B L CheukP Y Wong
Nov 30, 2000·American Journal of Physiology. Endocrinology and Metabolism·V Serazin-LeroyY Giudicelli
Jan 14, 2004·International Journal of Andrology·Yoshihiro OnoHidetoshi Yamanaka

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Citations

Apr 27, 2007·Current Urology Reports·Elahe A MostaghelDaniel W Lin
Jan 29, 2011·Retina·Farzin ForooghianCatherine B Meyerle
Jan 25, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Jingjing CaiYuan-Shan Zhu
May 29, 2007·Endocrine Journal·Falah ShidaifatZuhair Bani-Ismail
Sep 6, 2011·Endocrinology and Metabolism Clinics of North America·Wei Yang, Alice C Levine
Dec 3, 2013·The Prostate·Letitia WongWade Bushman
Oct 3, 2006·Urology·Bunzo KashiwagiKazuhiro Suzuki
May 12, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Philip P FitchevJennifer A Doll

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