Direct renin inhibition and the kidney.

Nature Reviews. Nephrology
Norman K Hollenberg

Abstract

Direct renin inhibition is a new means for blocking the renin-angiotensin system at the rate-limiting step of the cascade of events triggered by renin release--the interaction of renin with its physiological substrate angiotensinogen. The remarkable success of angiotensin-converting-enzyme inhibitors and angiotensin receptor blockers in the management of cardiovascular and renal disease has led to great interest in the potential of direct renin inhibitors. This Review focuses on the evidence that suggests that direct renin inhibitors might block the renin-angiotensin system in the kidney more completely than either angiotensin-converting-enzyme inhibitors or angiotensin receptor blockers. The therapeutic implications of this evidence are also reviewed, as well as the possible mechanistic routes by which direct renin inhibition might exert its influence on the kidney.

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Citations

May 22, 2010·Cardiovascular Drugs and Therapy·Christian W Mende
Dec 24, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hideyasu Kiyomoto, Kumiko Moriwaki
Nov 18, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Chiao-Yin SunMai-Szu Wu
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Mar 7, 2012·Cardiovascular Drugs and Therapy·Michel Azizi, Joël Ménard
Mar 16, 2012·Journal of Hypertension·Norman K Hollenberg
Oct 26, 2016·Bioorganic & Medicinal Chemistry·Yasuhiro ImaedaTakanobu Kuroita
Jun 3, 2021·Kidney Research and Clinical Practice·Sagar VermaVinant Bhargava
Oct 13, 2011·ACS Medicinal Chemistry Letters·Lanqi JiaDavid A Claremon

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