Direct role of the carboxy-terminal cell-binding domain of fibronectin in neural crest cell motility

Experimental Cell Research
A Beauvais-JouneauS Dufour

Abstract

We have analyzed the interaction of neural crest cells with fragments of fibronectin corresponding to the different spliced variants of the COOH-terminal cell-binding domain (COOH-ter CBD). We have shown that this domain can support cell adhesion and migration and that both the IIICS and HepII regions are involved in these events. The rate of locomotion is high, although undirectional, compared to that of whole fibronectin. Interactions with the COOH-ter CBD are controlled by alpha4beta1 and maybe other beta1 integrins and cell-surface proteoglycans. These receptors act cooperatively to mediate attachment, spreading, and migration on fibronectin.

References

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Citations

Jul 10, 2009·The Journal of Clinical Investigation·Ainara Vallejo-IllarramendiLouis F Reichardt
Jul 25, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·David J HeidenreichPhilip R Brauer
Jul 23, 2003·Developmental Biology·L R Strachan, M L Condic
Aug 31, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·D H Cai, P R Brauer
Jul 12, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Philip R Brauer, Thomas H Rosenquist
Oct 23, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S Testaz, J L Duband

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