Direct sampling of chemical weapons in water by photoionization mass spectrometry

Analytical Chemistry
J A SyageMatthew D Evans

Abstract

The vulnerability of water supplies to toxic contamination calls for fast and effective means for screening water samples for multiple threats. We describe the use of photoionization (PI) mass spectrometry (MS) for high-speed, high-throughput screening and molecular identification of chemical weapons (CW) threats and other hazardous compounds. The screening technology can detect a wide range of compounds at subacute concentrations with no sample preparation and a sampling cycle time of approximately 45 s. The technology was tested with CW agents VX, GA, GB, GD, GF, HD, HN1, and HN3, in addition to riot agents and precursors. All are sensitively detected and give simple PI mass spectra dominated by the parent ion. The target application of the PI MS method is as a routine, real-time early warning system for CW agents and other hazardous compounds in air and in water. In this work, we also present comprehensive measurements for water analysis and report on the system detection limits, linearity, quantitation accuracy, and false positive (FP) and false negative rates for concentrations at subacute levels. The latter data are presented in the form of receiver operating characteristic curves of the form of detection probability P(D)...Continue Reading

References

Jul 16, 1999·Analytical Chemistry·G S GroenewoldJ B Wright
Jan 13, 2000·Journal of the American Society for Mass Spectrometry·G S GroenewoldM Weibel
Jul 6, 2000·Analytical Chemistry·J Sherma
Jun 13, 2001·Journal of the American Society for Mass Spectrometry·J A SyageK A Hanold
Jul 25, 2003·Journal of Chromatography. a·Heiko Hayen, Uwe Karst
Sep 2, 2003·Mass Spectrometry Reviews·Andrea Raffaelli, Alessandro Saba
Nov 3, 2004·Journal of the American Society for Mass Spectrometry·Jack A Syage
Jan 1, 1999·Analytical Chemistry·R J Bartelt, B W Zilkowski

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Citations

Jan 26, 2017·Journal of the American Society for Mass Spectrometry·Chengyuan LiuYang Pan
Mar 14, 2018·Critical Reviews in Analytical Chemistry·Zygfryd WitkiewiczJavier Quagliano
Jan 31, 2007·Journal of Mass Spectrometry : JMS
Mar 13, 2014·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Shingo TerakadoNaoya Ohmura

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