PMID: 9437749Jan 23, 1998Paper

Direct stimulation of BAT thermogenesis does not affect hypothalamic neuropeptide Y

Peptides
C BingG Williams

Abstract

Acute cold exposure which significantly stimulated thermogenesis in brown adipose tissue (BAT), also increased neuropeptide Y (NPY) levels in its hypothalamic sites of release without affecting NPY synthesis, suggesting that NPY release is acutely inhibited. To clarify whether these changes in NPY are the cause or consequence of BAT activation, we studied whether hypothalamic NPY and NPY mRNA levels in rats were affected by acute intraperitoneal injection of the beta 3-adrenoceptor agonist BRL 35135 (500 micrograms/kg), which directly activates BAT thermogenesis. BRL 35135 treatment doubled BAT uncoupling protein mRNA levels (p < 0.05), and increased core temperature by 0.4 degree C (p < 0.05), but neither hypothalamic regional NPY levels nor hypothalamic NPY mRNA levels were affected by BRL 35135. This suggests that the NPY changes induced by cold exposure are not the result of BAT activation, and is consistent with the hypothesis that decreased NPY release during cold exposure might disinhibit the sympathetic innervation that drives BAT thermogenesis.

Citations

Nov 4, 2000·Expert Opinion on Investigational Drugs·H A WielandH N Doods
Dec 4, 2001·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Y Takakura, T Yoshida
Mar 29, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C J SmallS R Bloom

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.