Although hypercalcemia, osteoporosis, and increased bone turnover are associated with thyrotoxicosis, no direct effects of thyroid hormones on bone metabolism have been reported previously in organ culture. We have now demonstrated that prolonged treatment with thyroxine (T4) or triiodothyronine (T3) can directly increase bone resorption in cultured fetal rat long bones as measured by the release of previously incorporated 45Ca. T4 and T3 at 1 muM to 10 nM increased 45Ca release by 10-60% of total bone 45Ca during 5 days of culture. The medium contained 4 mg/ml of bovine serum albumin to which 90% of T4 and T3 were bound, so that free concentrations were less than 0.1 muM. The response to T4 and T3 was inhibited by cortisol (1 muM) and calcitonin (100 mU/ml). Indomethacin did not inhibit T4 response suggesting that T4 stimulation of bone resorption was not mediated by increased prostaglandin synthesis by the cultured bone. Matrix resorption was demonstrated by a decrease in extracted dry weight and hydroxyproline concentration of treated bones and by histologic examination which also showed increased osteoclast activity. The effects of thyroid hormones were not only slower than those of other potent stimulators of osteoclastic ...Continue Reading
Cyclic nucleotide phosphodiesterase from bone: characterization of the enzyme and studies of inhibition by thyroid hormones
Role of adenosine-3',5'-monophosphate in the hormonal regulation of bone resorption: studies with cultured fetal bone
The effects of dibutyryl cyclic AMP, aminophylline and propranolol on PTE-induced bone resorption in vitro
Cyclic adenosine 3',5'-monophosphate concentration in plasma, adipose tissue and skeletal muscle in normal subjects and in patients with hyper- and hypothyroidism
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Effect of phosphate, calcium and magnesium on bone resorption and hormonal responses in tissue culture
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Long-term organ culture of embryonic chick femora: a system for investigating bone and cartilage formation at an intermediate level of organization
Comparison of the effects of 3,5,3'-triiodothyroacetic acid and triiodothyronine on bone resorption in cultured fetal rat long bones and neonatal mouse calvariae
Triiodothyronine potentiates the stimulatory effects of interleukin-1 beta on bone resorption and medium interleukin-6 content in fetal rat limb bone cultures
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Possible limited bone loss with suppressive thyroxine therapy is unlikely to have clinical relevance
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Thyroid hormone inhibits growth and stimulates terminal differentiation of epiphyseal growth plate chondrocytes
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Symptomatic hypercalcemia due to painless thyroiditis after unilateral adrenalectomy in a patient with Cushing's syndrome
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Degradative processes of connective tissue proteins with special emphasis on collagenolysis and bone resorption
Osteogenic differentiation of bone marrow mesenchymal stem cells of ovariectomized and non-ovariectomized female rats with thyroid dysfunction
Evaluation of calcium and lead interaction, in addition to their impact on thyroid functions in hyper and hypothyroid patients
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Genetic analysis and effect of triiodothyronine and prednisone trial on bone turnover in a patient with craniotubular hyperostosis
Radiopharmacological profiles of tracers under pathophysiological conditions. 99mTc-methylene diphosphonate uptake by bone in altered thyroid status
The biphasic effect of triiodothyronine compared to bone resorbing effect of PTH on bone modelling of mouse long bone in vitro
Concomitant Graves' disease and primary hyperparathyroidism. Influence of hyperthyroidism on serum calcium and parathyroid hormone
Reduction by propranolol of urinary hydroxyproline excretion in human hyperthyroidism: a beta-receptor blockade effect or a membrane stabilizing mechanism?
A controlled study of the effects of thyrotoxicosis and propranolol treatment on mineral metabolism and parathyroid hormone immunoreactivity
Kinetics of trabecular bone resorption and formation in hypothyroidism: evidence for a positive balance per remodeling cycle
Osteopenia, pathological fractures, and increased urinary calcium excretion in schizophrenic patients with polydipsia
Bone-resorbing activity of thyroid hormones is related to prostaglandin production in cultured neonatal mouse calvaria
Thyroid hormone 5'-deiodinase activity, nuclear binding, and effects on mitogenesis in UMR-106 osteoblastic osteosarcoma cells
Effect of propranolol treatment on bone mass, bone mineral content, bone remodelling, parathyroid function and vitamin D metabolism in hyperthyroidism
Risk factors for reduced skin thickness and bone density: possible clues regarding pathophysiology, prevention, and treatment
Increased adipogenesis in bone marrow but decreased bone mineral density in mice devoid of thyroid hormone receptors
Parathyroidectomy for primary hyperparathyroidism induces positive uncoupling and increases bone mineral density in cancellous bones
The early effects of radioiodine therapy for hyperthyroidism on biochemical indices of bone turnover
Response of trabecular bone, thyroid C and follicular cells to synthetic salmon calcitonin in middle-aged orchidectomized male rats
Excess Maternal Thyroxine Alters the Proliferative Activity and Angiogenic Profile of Growth Cartilage of Rats at Birth and Weaning
Thyroid hormone stimulates osteoclast differentiation by a mechanism independent of RANKL-RANK interaction
Thyroid hormones increase insulin-like growth factor mRNA levels in the clonal osteoblastic cell line MC3T3-E1
Skeletal morphogenesis in the urodele skull: II. Effect of developmental stage in thyroid hormone-induced remodeling
A thyrotoxic skeletal phenotype of advanced bone formation in mice with resistance to thyroid hormone
Anatomical Assessment of the Adult Skeleton of Zebrafish Reared Under Different Thyroid Hormone Profiles
Lack of the Thyroid Hormone Transporter Mct8 in Osteoblast and Osteoclast Progenitors Increases Trabecular Bone in Male Mice
Type 2 Deiodinase Thr92Ala Polymorphism is Associated with a Reduction in Bone Mineral Density: A Community-based Korean Genome and Epidemiology Study
Fibroblast growth factor-23 in patients with Graves' disease before and after antithyroid therapy: its important role in serum phosphate regulation
Vitamin D toxicity due to a commonly available "over the counter" remedy from the Dominican Republic
Hypercalcemia in hyperthyroidism: patterns of serum calcium, parathyroid hormone, and 1,25-dihydroxyvitamin D3 levels during management of thyrotoxicosis.
Elevated bone resorption markers in a patient with hypercalcemia associated with post-partum thyrotoxicosis and hypoadrenocorticism due to pituitary failure
Early changes in parameters of bone and mineral metabolism during therapy for hyper- and hypothyroidism
Serum concentrations of osteocalcin in patients with hyperthyroidism, hypothyroidism and subacute thyroiditis
Effects of alendronate on bone loss in pre- and postmenopausal hyperthyroid women treated with methimazole
A tetracycline-based histomorphometric evaluation of bone resorption and bone turnover in hyperthyroidism and hyperparathyroidism
Sclerostin Blockade and Zoledronic Acid Improve Bone Mass and Strength in Male Mice With Exogenous Hyperthyroidism
Increased rat femur osteocalcin mRNA concentrations following in vivo administration of thyroid hormone
Effects of treatment of hyperthyroidism on glucose homeostasis, insulin secretion, and markers of bone turnover.
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