Direct stimulation of ghrelin secretion by sympathetic nerves

Endocrinology
Thomas O MundingerGerald J Taborsky

Abstract

The hormone ghrelin is secreted mainly from the gut, rises in peripheral plasma before meals, and is implicated in stimulating hunger, initiating meals, and developing obesity. We hypothesize that activation of the sympathetic nervous system contributes to preprandial ghrelin surges. The present studies in isoflurane-anesthetized Wistar rats were designed to determine whether sympathetic nerves and neurohormones are capable of stimulating ghrelin secretion. We activated gut sympathetic nerves by two methods: electrical sympathetic nerve stimulation (SNS) and chemical sympathetic nerve activation with iv tyramine (TYR) administration. Portal venous blood was sampled before and during a 10-min sympathetic stimulation. Successful activation of gut sympathetic nerves was verified by increments in portal venous norepinephrine. SNS increased portal ghrelin by 206 +/- 50%. In contrast, simply isolating gut sympathetic nerves without applying current had a minimal effect on ghrelin levels. TYR also increased portal ghrelin [change (Delta), +52 +/- 11%], whereas saline infusion had little effect. We next determined whether the neural stimulation of ghrelin secretion was mediated indirectly via the suppression of insulin secretion during...Continue Reading

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Citations

Jun 17, 2008·Nature Neuroscience·Michael LutterJeffrey M Zigman
Oct 3, 2012·Nature Reviews. Gastroenterology & Hepatology·Charlotte X Dong, Patricia L Brubaker
Aug 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Tong-Jin ZhaoJeffrey M Zigman
Jun 11, 2011·Current Opinion in Clinical Nutrition and Metabolic Care·Guglielmo Beccuti, Silvana Pannain
Sep 25, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Ken-ichi TakahashiMichiaki Mishima
Oct 23, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·N A AzizR A C Roos
Mar 15, 2012·American Journal of Physiology. Endocrinology and Metabolism·Ichiro SakataJeffrey M Zigman
Aug 7, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jun ZhengToku Takahashi
Nov 6, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Reji BabygirijaToku Takahashi
Jan 4, 2007·The Journal of Clinical Investigation·David E Cummings, Joost Overduin
Jun 28, 2011·The Journal of Clinical Investigation·Jen-Chieh ChuangJeffrey M Zigman
Apr 24, 2012·Journal of Neurogastroenterology and Motility·Andreas Stengel, Yvette Taché
Jul 18, 2014·Psychoneuroendocrinology·Lisa M JaremkaJanice K Kiecolt-Glaser
Jun 1, 2014·Appetite·Danielle Marques Macedo, Rosa Wanda Diez-Garcia
Jan 20, 2016·Current Hypertension Reports·Yuanjie MaoIchiro Kishimoto
Jan 27, 2016·Molecular Neurobiology·Limin ShiJunxia Xie
Mar 1, 2015·Hormones and Behavior·Lisa M JaremkaJanice K Kiecolt-Glaser
Jul 4, 2012·Pharmacology & Therapeutics·Harriët SchellekensJohn F Cryan
Mar 31, 2012·Biological Psychiatry·Mario Perelló, Jeffrey M Zigman
Feb 15, 2011·Physiology & Behavior·Hans-Rudolf BerthoudHuiyuan Zheng
May 26, 2009·Peptides·Xiao-Ying DongXiao-Ting Zou
Dec 9, 2008·Psychoneuroendocrinology·Sarosh J MotivalaMichael R Irwin
Oct 3, 2014·Endocrine Journal·Hiroshi IwakuraKazuwa Nakao
May 17, 2008·Regulatory Peptides·Hans-Rudolf Berthoud
Mar 18, 2008·Life Sciences·Masahiro OchiTetsuo Arakawa
Dec 5, 2015·Journal of Physiology and Biochemistry·Christian CarpénéJeanne Mialet-Perez
Mar 31, 2007·Drug Discovery Today·Adelino F Leite-Moreira, João-Bruno Soares
Jun 5, 2015·Molecular Metabolism·T D MüllerM H Tschöp
Sep 30, 2009·Journal of Peptide Science : an Official Publication of the European Peptide Society·Constance CholletAnnette G Beck-Sickinger
Feb 5, 2011·Diabetes/metabolism Research and Reviews·Haiko SchloeglMichael Stumvoll
Jan 14, 2012·Obesity·Petra SchüsslerAxel Steiger
Jul 20, 2010·Scandinavian Journal of Medicine & Science in Sports·W SausengH Zotter
Dec 12, 2013·Molecular Metabolism·Maja S EngelstoftThue W Schwartz
May 20, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Heba Abdel-AzizMohamed T Khayyal
Aug 8, 2014·Frontiers in Endocrinology·Chooi Yeng Lee, Alfonso Abizaid
Feb 24, 2015·International Journal of Endocrinology·Yuki ShiimuraMasayasu Kojima
Aug 23, 2016·The Journal of Clinical Investigation·Bharath K ManiJeffrey M Zigman

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