Direct stimulation of optic nerve by electrodes implanted in optic disc of rabbit eyes

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Xiaoyun FangYasuo Tano

Abstract

To determine whether wire microelectrodes implanted in the optic disc can be used to elicit cortical potentials. Two or four platinum wire electrodes of two types, viz., the cut-end type and the exposed-tip type, were inserted through the vitreous and fixed in the optic disc of 16 rabbit eyes. Electrically evoked potentials (EEPs) were recorded after bipolar electrical stimulation with the two wire electrodes and by different combinations of the four-electrode system. The optic discs were examined histologically after the experiment. The wire electrodes were successfully implanted and fixed into different positions of the optic disc without serious complications in all 16 eyes. EEPs could be elicited after bipolar electrical stimulation of the optic nerve using either the two-electrode system or different pairs of the four-electrode system. Threshold charge densities to elicit EEPs were 0.32-0.64 mC/cm(2) in eyes using the cut-end type of electrodes and 0.93-6.21 muC/cm(2) in eyes using the exposed-tip type. The amplitude of the EEPs increased with increasing electrical stimulus intensities. Histological evaluation revealed limited damage to the neural tissue adjacent to the electrode track. The visual cortex can be activated b...Continue Reading

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Citations

Nov 8, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Liming LiQiushi Ren
Nov 7, 2009·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Hirokazu SakaguchiYasuo Tano
Apr 10, 2012·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Hirokazu SakaguchiKohji Nishida
Dec 4, 2008·Documenta Ophthalmologica. Advances in Ophthalmology·Changsi CaiQiushi Ren
Aug 5, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Xiaoyun FangYasuo Tano
Jun 24, 2009·Optometry : Journal of the American Optometric Association·Kelly ShintaniAndrew S Gurwood
May 18, 2011·Clinical & Experimental Ophthalmology·Jong Min Ong, Lyndon da Cruz
Sep 19, 2008·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·Xinyu ChaiQiushi Ren
Aug 1, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Pengjia CaoLiming Li
Sep 9, 2015·Frontiers in Neuroscience·Diego Ghezzi
Apr 23, 2015·Brain Stimulation·Kentaro NishidaKohji Nishida
Mar 3, 2006·Vision Research·Walter G SannitaPiergiorgio Picozza
Aug 21, 2007·Journal of Biomaterials Science. Polymer Edition·Jessica O WinterJoseph F Rizzo
Nov 23, 2006·Lancet·Dyonne T HartongThaddeus P Dryja

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