Direct Synthesis of Peptide-Containing Silicones: A New Way to Bioactive Materials.

Chemistry : a European Journal
Julie MartinAhmad Mehdi

Abstract

A simple and efficient way to synthesize peptide-containing silicone materials is described. Silicone oils containing a chosen ratio of bioactive peptide sequences were prepared by acid-catalyzed copolymerization of dichlorodimethylsilane, hybrid dichloromethyl peptidosilane, and Si(vinyl)- or SiH-functionalized monomers. Functionalized silicone oils were first obtained and then, after hydrosilylation cross-linking, bioactive polydimethylsiloxane (PDMS)-based materials were straightforwardly obtained. The introduction of an antibacterial peptide yielded PDMS materials showing activity against Staphylococcus aureus. PDMS containing RGD ligands showed improved cell-adhesion properties. This generic method was fully compatible with the stability of peptides and thus opened the way to the synthesis of a wide range of biologically active silicones.

References

Sep 29, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R O Darouiche
Apr 9, 2004·The New England Journal of Medicine·Rabih O Darouiche
Jan 19, 2006·Bioconjugate Chemistry·Hong ChenBettina Klenkler
Sep 28, 2007·Journal of Biomedical Materials Research. Part a·Hirotaka Maeda, Toshihiro Kasuga
Jan 8, 2010·Biofouling·Kristof De PrijckHans J Nelis
Feb 16, 2013·Chemical Reviews·Pamela N NgeAdam T Woolley
Feb 28, 2013·Analytical and Bioanalytical Chemistry·Rui ZhangChun Chau Sze
Nov 16, 2013·Chemical Communications : Chem Comm·Molly J CarrollPamela K Kreeger
Jun 24, 2014·Actas urologicas españolas·L García-AparicioJ Rodó
Feb 5, 2015·Angewandte Chemie·Said JeborsGilles Subra
Feb 18, 2015·Journal of Peptide Science : an Official Publication of the European Peptide Society·Said JeborsGilles Subra
Apr 6, 2016·Regenerative Biomaterials·Joseph C SalamoneRebecca E McMahon
Oct 30, 2016·Advanced Healthcare Materials·Coline PineseGilles Subra
Mar 28, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Nicolas MasurierGilles Subra
Mar 28, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Biswajit MishraSusanna Su Jan Leong

❮ Previous
Next ❯

Citations

Feb 10, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria NowackaAnna Kowalewska

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.