Direct trans-activation of the human cyclin D2 gene by the oncogene product Tax of human T-cell leukemia virus type I

Oncogene
Y HuangM Nakamura

Abstract

Cyclins are one of the pivotal determinants regulating cell cycle progression. We previously reported that the trans-activator Tax of human T-cell leukemia virus type I (HTLV-I) induces endogenous cyclin D2 expression along with cell cycle progression in a resting human T-cell line, Kit 225, suggesting a role of cyclin D2 in Tax-mediated cell cycle progression. The cyclin D2 gene has a typical E2F binding element, raising the possibility that induction of cyclin D2 expression is a consequence of cell cycle progression. In this study, we examined the role and molecular mechanism of induction of the endogenous human cyclin D2 gene by Tax. Introduction of p19(INK4d), a cyclin dependent kinase (CDK) inhibitor of the INK4 family specific for D-type CDK, inhibited Tax-mediated activation of E2F, indicating requirement of D-type CDK in Tax-mediated activation of E2F. Previously indicated E2F binding element and two NF-kappaB-like binding elements in the 1.6 kbp cyclin D2 promoter fragment had little, if any, effect on responsiveness to Tax. We found that trans-activation of the cyclin D2 promoter by Tax was mainly mediated by a newly identified NF-kappaB-like element with auxiliary contribution of a CRE-like element residing in sequen...Continue Reading

References

Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P GunningL Kedes
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R GrassmannW A Haseltine
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B J PoieszR C Gallo
Sep 1, 1982·Molecular and Cellular Biology·C M GormanB H Howard
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M YoshidaY Hinuma
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·Y HinumaI Miyoshi
Jan 1, 1995·Journal of Cancer Research and Clinical Oncology·M Yoshida
Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·W J GrossmanL Ratner
Apr 12, 1996·The Journal of Biological Chemistry·A R BrooksP G Milner
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·M A IkedaJ R Nevins
Dec 6, 1996·Science·C J Sherr
Aug 8, 1998·Genes & Development·N Dyson

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Citations

Dec 23, 2003·International Journal of Hematology·Genoveffa FranchiniJake R Fullen
Sep 13, 2005·Oncogene·Susan J Marriott, Oliver John Semmes
Jun 10, 2008·Current Opinion in Hematology·Zhi-Wei LiJames R Berenson
Dec 6, 2012·Leukemia Research and Treatment·Nishat AliyaPooja Jain
Jan 17, 2009·Retrovirology·Yoshiaki MachijimaNaoki Mori
May 22, 2004·Neoplasia : an International Journal for Oncology Research·Noriko HironakaShoji Yamaoka
Jul 13, 2004·The Journal of Investigative Dermatology·Naoko Kanda, Shinichi Watanabe
Nov 4, 2004·International Journal of Cancer. Journal International Du Cancer·Mariko WatanabeRyouichi Horie
Mar 25, 2006·International Journal of Cancer. Journal International Du Cancer·Sankichi HoriuchiNaoki Yamamoto
Sep 18, 2008·International Journal of Cancer. Journal International Du Cancer·Chie IshikawaNaoki Mori
Feb 6, 2007·International Journal of Cancer. Journal International Du Cancer·Taeko OkudairaNaoki Mori
Jan 12, 2011·Biochemical Pharmacology·Tomoyuki TsumurayaNaoki Mori
Mar 25, 2006·Future Oncology·Mickey C-T Hu, M C Hung
Jun 1, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·Takahiro TsujiTakashi Yoshiki
Sep 13, 2005·Oncogene·Ralph GrassmannKuan-Teh Jeang
Feb 15, 2015·Molecular Systems Biology·Maxim N ShokhirevAlexander Hoffmann
Aug 19, 2006·Blood·Jean-Michel MesnardChristian Devaux
Aug 12, 2003·Oncogene·Michael L GatzaSusan J Marriott
Apr 20, 2004·The Journal of Biological Chemistry·Kuan-Teh JeangMordechai Aboud
Aug 9, 2016·International Journal of Oncology·Chie IshikawaNaoki Mori
Feb 20, 2019·Frontiers in Immunology·Marion MussbacherJohannes A Schmid
Apr 3, 2020·Molecular Biology Reports·George I LambrouSpiros Vlahopoulos
Jan 24, 2019·Dose-response : a Publication of International Hormesis Society·Iram FatimaTariq Mahmood

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