Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration

Nature Neuroscience
Fanny HerissonMatthias Nahrendorf

Abstract

Innate immune cells recruited to inflammatory sites have short life spans and originate from the marrow, which is distributed throughout the long and flat bones. While bone marrow production and release of leukocyte increases after stroke, it is currently unknown whether its activity rises homogeneously throughout the entire hematopoietic system. To address this question, we employed spectrally resolved in vivo cell labeling in the murine skull and tibia. We show that in murine models of stroke and aseptic meningitis, skull bone marrow-derived neutrophils are more likely to migrate to the adjacent brain tissue than cells that reside in the tibia. Confocal microscopy of the skull-dura interface revealed myeloid cell migration through microscopic vascular channels crossing the inner skull cortex. These observations point to a direct local interaction between the brain and the skull bone marrow through the meninges.

References

Nov 1, 1986·Journal of Neurosurgery·D A GamacheE F Ellis
Jan 1, 1996·Anatomy and Embryology·W Zenker, S Kubik
Mar 30, 1999·American Journal of Physical Anthropology·I HershkovitzG Leonetti
Jan 30, 2004·Journal of Neuropathology and Experimental Neurology·William D HillSimon J Conway
Jun 9, 2005·The Journal of Experimental Medicine·Yoshihiro UedaGarnett Kelsoe
Aug 27, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Halina OffnerPatricia D Hurn
Dec 21, 2007·Lab on a Chip·Thomas M Keenan, Albert Folch
Dec 14, 2011·The New England Journal of Medicine·Claudia F LucchinettiRichard M Ransohoff
Apr 25, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Nimer AdeebAaron A Cohen-Gadol
Jul 12, 2012·Archives of Neurology·Hooman Kamel, Costantino Iadecola
Jan 12, 2013·Science·Filip K Swirski, Matthias Nahrendorf
Nov 12, 2013·Cell Reports·Jean-Philippe MichaudSerge Rivest
Nov 26, 2013·Nature Immunology·Arby AbtinWolfgang Weninger
Dec 4, 2013·JAMA Neurology·Gabriel CourtiesMatthias Nahrendorf
Jan 17, 2014·Nature·Sean J Morrison, David T Scadden
Jun 24, 2014·Nature Medicine·Timo HeidtMatthias Nahrendorf
Aug 20, 2014·The American Journal of Pathology·Ahmet AracGary K Steinberg
Aug 26, 2014·Methods in Molecular Biology·Iva Lelios, Melanie Greter
Nov 2, 2014·Circulation Research·Gabriel CourtiesMatthias Nahrendorf
Dec 31, 2014·Acta Neuropathologica·Isabel Perez-de-PuigAnna M Planas
Jan 8, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Craig M McKittrickHilary V O Carswell
Mar 13, 2015·PLoS Pathogens·Philipp KrugerDominik Hartl
Mar 26, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Glen C JicklingFrank R Sharp
Jun 17, 2015·The Journal of Experimental Medicine·Aleksanteri AspelundKari Alitalo
Jul 27, 2015·Ageing Research Reviews·Mathias GelderblomTim Magnus
Oct 16, 2015·The Journal of Experimental Medicine·Stefan ProkopFrank L Heppner
Oct 27, 2015·American Journal of Physical Anthropology·Gizéh Rangel de LázaroEmiliano Bruner
May 19, 2017·Circulation Research·Laibaik ParkCostantino Iadecola
Aug 7, 2017·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Giuseppe FaracoCostantino Iadecola

❮ Previous
Next ❯

Citations

Mar 9, 2019·Expert Review of Neurotherapeutics·Monica J KillenKeri Lh Carpenter
Jan 9, 2020·Nature Reviews. Neuroscience·John V Pluvinage, Tony Wyss-Coray
Jan 4, 2020·Nature Reviews. Neuroscience·Hiroki R UedaPhilipp J Keller
Dec 21, 2019·Science·Justin Rustenhoven, Jonathan Kipnis
Apr 3, 2020·Annals of Neurology·Nouchine HadjikhaniMichael A Moskowitz
May 30, 2020·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Adil AsgharShagufta Naaz
Jan 7, 2020·Aging·Jiayan WuXueyuan Liu
Sep 8, 2020·Cell Communication and Signaling : CCS·Alexandre H LopesThiago M Cunha
Dec 24, 2018·Acta Neuropathologica·Amaia Otxoa-de-AmezagaAnna M Planas
May 16, 2019·Stroke; a Journal of Cerebral Circulation·Amaia Otxoa-de-AmezagaAnna M Planas
Oct 30, 2019·Journal of Neuroinflammation·Aurélie SoubéranGeneviève Rougon
Jan 10, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Pavel YanevAnn M Stowe
Dec 27, 2018·Journal of Internal Medicine·M Nahrendorf
Aug 10, 2019·Nature Reviews. Rheumatology·Anika GrüneboomMatthias Gunzer
Aug 7, 2019·Nature Biomedical Engineering·John F Zimmerman, Bozhi Tian
Jul 14, 2019·Science Immunology·Panagiotis Mastorakos, Dorian McGavern
Jul 5, 2019·Nature Nanotechnology·Héctor Acarón LedesmaBozhi Tian
Apr 5, 2020·Nutrients·Maxine D RouvroyeMarios Hadjivassiliou
Oct 22, 2019·Frontiers in Immunology·Lucas J M Perus, Logan A Walsh
Oct 18, 2019·Nature Metabolism·Anika GrüneboomMatthias Gunzer
Apr 22, 2020·Nature Nanotechnology·Max L SendersWillem J M Mulder
Apr 24, 2020·Frontiers in Pharmacology·Hélène GrégoireEmmanuel Garcion
Jan 8, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zachary PapadopoulosJonathan Kipnis
Nov 7, 2019·Nature Metabolism·Christopher Ritchlin, Iannis E Adamopoulos
Jul 11, 2020·Science·Tatiana V Petrova, Gou Young Koh
May 12, 2020·The Journal of Clinical Investigation·Costantino IadecolaJosef Anrather
Jan 9, 2019·Frontiers in Neuroscience·Peter Van Dyken, Baptiste Lacoste
Dec 24, 2018·Temperature : Multidisciplinary Biomedical Journal·Fabian Johannes PfliegerChristoph Rummel
Oct 2, 2019·Bioengineering & Translational Medicine·Lauren A HerronHasan E Abaci
Aug 15, 2019·Journal of Neuroinflammation·Giulia Di BenedettoGiuseppina Cantarella
May 16, 2019·Nature Methods·Feifei WangHongjie Dai
Apr 20, 2019·Frontiers in Cellular Neuroscience·Ahmet AracGary K Steinberg
Nov 17, 2020·Journal of Neurotrauma·Darragh R WalshJohn J E Mulvihill
Jan 6, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Valeria RamagliaJennifer L Gommerman
Oct 23, 2020·Nuclear Medicine and Molecular Imaging·Dong Soo LeeYoori Choi
Feb 27, 2021·Headache·Håkan Ashina, Michael A Moskowitz

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Methods Mentioned

BETA
flow cytometry
flow
flow-cytometry
confocal microscopy
enzyme-linked immunosorbent assay
ELISA
confocal microcopy
X-ray
dissection
fluorescence

Software Mentioned

FlowJo
Amira
ARRIVE
Affinity Designer
Matlab
GraphPad Prism
Imaris

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