PMID: 7526116Jan 1, 1994Paper

Direct visualization and measurements of wound neovascularization: application in microsurgery research

Microsurgery
D KjolsethL J Weiner

Abstract

Neovascularization or angiogenesis is an essential yet poorly understood component of the healing process. In wound healing research, there is a lack of models enabling quantitative and continuous measurements of wound neovascularization. The hairless mouse ear wound model permits quantitative measurements of wound epithelialization and neovascularization continuously throughout the healing process. On the ears of male homozygous (hr/hr) hairless mice, standardized circular full thickness dermal wounds are produced; then, using vital microscopy, these two processes are directly viewed and measured at day 0 and every third day thereafter until these are complete. This model system and its application to clinically relevant situations are reviewed.

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Citations

Feb 19, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·W MayerR Fundele
Nov 6, 2012·The Journal of Surgical Research·Anna L SanderHeike Jakob
Feb 11, 2005·Lasers in Surgery and Medicine·Lene HedelundThomas Poulsen
Mar 27, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Anna L SanderJohannes M Frank
Oct 31, 2007·Clinics in Plastic Surgery·Robert J Morin, Nancy L Tomaselli
Apr 25, 2006·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Markus M ZimmerHans Becker
Feb 24, 2006·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·S LangerS Mueller
Apr 11, 2000·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·L H TerkelsenV E Hjortdal
Jul 1, 1998·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·K BangV E Hjortdal
Apr 5, 2021·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Katharina SommerAnna L Sander

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