PMID: 9544939Apr 17, 1998Paper

Directed biosynthesis of peptaibol antibiotics in two Trichoderma strains. II. Structure elucidation

The Journal of Antibiotics
G LeclercB Bodo

Abstract

Alpha-aminoisobutyric acid-directed biosynthesis in two Trichoderma strains has been shown to lead to the simplification of the natural peptaibol microheterogeneous mixtures and to the production of new analogues. Hence, two new peptides originating from T. harzianum, trichorzin PA(U) 4 and harzianin PCU 4, were isolated by HPLC. Their sequences were determined by positive liquid secondary-ion mass spectrometry (LSI MS). Trichorzin PA(U) 4 and harzianin PC(U) 4 are 18- and 14-residue peptaibols, respectively, both containing a high proportion of alpha-aminoisobutyric acid (Aib). LSI MS performed with lithium cationized peptides, allowed to assign the relative position of leucine/isoleucine isomeric residues, even without the use of tandem mass spectrometry.

Citations

Sep 26, 2008·Chemistry & Biodiversity·Thomas Degenkolb, Hans Brückner
May 16, 2020·Journal of Fungi·Xiaoyan NiuQiongbo Hu
Jul 12, 2005·Acta Microbiologica Et Immunologica Hungarica·A SzekeresCs Vágvölgyi
Sep 28, 2007·Natural Product Reports·Juliana F de S Daniel, Edson Rodrigues Filho
Nov 17, 2007·Rapid Communications in Mass Spectrometry : RCM·Norbert StoppacherRainer Schuhmacher
Dec 9, 2003·Journal of Peptide Science : an Official Publication of the European Peptide Society·Thomas DegenkolbUdo Gräfe
Jun 30, 2012·Journal of Peptide Science : an Official Publication of the European Peptide Society·Sloan AyersNicholas H Oberlies
Jun 26, 2007·Chemistry & Biodiversity·Balázs LeitgebLászló Kredics

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