Directed C-H Bond Functionalization: A Unified Approach to Formal Syntheses of Amorfrutin A, Cajaninstilbene Acid, Hydrangenol, and Macrophyllol

The Journal of Organic Chemistry
Gowri Sankar GrandhiMahiuddin Baidya

Abstract

Formal syntheses of natural products amorfrutin A, cajaninstilbene acid, hydrangenol, and macrophyllol have been accomplished on the basis of successive C-H bond functionalization of ready-stock benzoic acids. This concise strategy involves transition-metal-catalyzed directed C-H olefination, C-H hydroxylation, and acid-mediated C-H prenylation as key steps.

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Citations

May 28, 2019·Bioscience, Biotechnology, and Biochemistry·Tadafumi FujitaYusuke Ogura
Mar 5, 2021·The Journal of Organic Chemistry·Brian J CurtisFrank C Schroeder
Aug 27, 2021·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Sandeep KumarPralay Das

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