Directed glial differentiation and transdifferentiation for neural tissue regeneration

Experimental Neurology
Justyna JanowskaJoanna Sypecka

Abstract

Glial cells which are indispensable for the central nervous system development and functioning, are proven to be vulnerable to a harmful influence of pathological cues and tissue misbalance. However, they are also highly sensitive to both in vitro and in vivo modulation of their commitment, differentiation, activity and even the fate-switch by different types of bioactive molecules. Since glial cells (comprising macroglia and microglia) are an abundant and heterogeneous population of neural cells, which are almost uniformly distributed in the brain and the spinal cord parenchyma, they all create a natural endogenous reservoir of cells for potential neurogenerative processes required to be initiated in response to pathophysiological cues present in the local tissue microenvironment. The past decade of intensive investigation on a spontaneous and enforced conversion of glial fate into either alternative glial (for instance from oligodendrocytes to astrocytes) or neuronal phenotypes, has considerably extended our appreciation of glial involvement in restoring the nervous tissue cytoarchitecture and its proper functions. The most effective modulators of reprogramming processes have been identified and tested in a series of pre-clin...Continue Reading

Citations

May 31, 2019·International Journal of Molecular Sciences·Natalia NowickaJoanna Wojtkiewicz
Dec 18, 2018·Frontiers in Cellular Neuroscience·Lyujie FangRaymond C B Wong
Jan 24, 2019·International Journal of Molecular Sciences·Celeste Caruso BavisottoClaudia Campanella
Jun 10, 2021·Neuroscience Bulletin·Yang Zhang, Donghong Cui
Jun 15, 2021·Frontiers in Neuroscience·Xiaohuan ZhaoXiaodong Sun

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

Comptes rendus des séances de la Société de biologie et de ses filiales
S VincentAngela Giangrande
The International Journal of Biochemistry & Cell Biology
Kristjan R Jessen
Journal of Neuroscience Methods
Tsuneko MishimaHajime Hirase
© 2022 Meta ULC. All rights reserved