Directed-sorting method for synthesis of bead-based combinatorial libraries of heterogeneous catalysts

Journal of Combinatorial Chemistry
Ramanathan RamnarayananRichard R Willis

Abstract

The synthesis and analysis of inorganic material combinatorial libraries by a directed-sorting, split-pool bead method was demonstrated. Directed-sorting, split-pool, metal-loaded libraries were synthesized by adsorbing metal salts (H2PtCl6, SnCl2, CuCl2, and NiCl2) and metal standards (Pt, Cu, Ni in HCl) onto 2-mg porous gamma-alumina beads in 96- or 384-well plates. A matrix algorithm for the synthesis of bead libraries treated each bead as a member of a row or column of a given matrix. Computer simulations and manual tracking of the sorting process were used to assess library diversity. The bead compositions were analyzed by energy-dispersive X-ray spectroscopy, X-ray fluorescence spectroscopy, electron probe microanalysis, inductively coupled plasma atomic emission spectroscopy, and inductively coupled plasma mass spectroscopy. The metal-loaded beads were analyzed by laser-activated membrane introduction mass spectroscopy (LAMIMS) for catalytic activity using methylcyclohexane dehydrogenation to toluene as a probe reaction. The catalytic activity of individual beads that showed minimal (approximately 20% of that of Pt on alumina) to high conversion could be determined semiquantitatively by LAMIMS. This method, therefore, pr...Continue Reading

References

Apr 4, 2000·Journal of Combinatorial Chemistry·M Lebl
Apr 1, 1997·Chemical Reviews·Kit S. LamViktor Krchnák
Nov 12, 2002·Journal of Combinatorial Chemistry·Yipeng SunRichard R Willis
Feb 22, 2003·Angewandte Chemie·Sergey A Kozmin, Ying Wang
Nov 16, 2004·Chemical Communications : Chem Comm·Chelsey D BaertschKlavs F Jensen
Jun 23, 1995·Science·X D XiangP G Schultz

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Citations

May 3, 2013·Journal of the American Society for Mass Spectrometry·Mohosin SarkarMichael J Chalmers
Jun 8, 2011·ACS Combinatorial Science·Radislav PotyrailoHubert Lam
Apr 22, 2008·Current Opinion in Chemical Biology·A Ganesan

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