Directing-Group-Enabled Cycloaddition of Azides and Alkynes toward Functionalized Triazoles

Organic Letters
Linwei ZengSunliang Cui

Abstract

Herein, we report a directing-group-enabled Huisgen cycloaddition of azides and alkynes for the synthesis of functionalized triazoles in which the triazene group could act as a directing group to enable this regioselective [3 + 2] cycloaddition and further replacement by diverse groups, including amino, amide, halogen, and heterocycle substituents. This method represents a general and practical synthesis of triazoles under mild reaction conditions and broad substrate scope.

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