Directing/protecting-group-free synthesis of tetraaryl-substituted pyrazoles through four direct arylations on an unsubstituted pyrazole scaffold

Chemistry : a European Journal
Shinichiro FuseHiroshi Tanaka

Abstract

A directing/protecting-group-free synthesis of 1,3,4,5-tetraaryl-substituted pyrazoles was achieved through four transition metal-catalyzed direct arylations. Various pyrazoles with four different aryl rings were obtained using readily available reagents from an unsubstituted pyrazole. Two aryl-substituted pyrazoles showed intense violet fluorescence, high quantum yields (Φf =0.68, 0.64), and large Stokes shifts (19000, 15200 cm(-1) ).

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Citations

Dec 3, 2016·Angewandte Chemie·Fabio de MolinerMarc Vendrell
Jan 11, 2017·Chemical Communications : Chem Comm·Shin Suzuki, Junichiro Yamaguchi
Oct 5, 2017·Angewandte Chemie·Shin SuzukiJunichiro Yamaguchi
Jul 25, 2020·Organic & Biomolecular Chemistry·Eunsu KangJung Min Joo
Oct 23, 2019·The Journal of Organic Chemistry·Kazumasa TanimotoHiroki Iida
Dec 29, 2020·The Journal of Organic Chemistry·Savio CardozaVibha Tandon

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