Direction-dependent conduction in lone atrial fibrillation

Heart Rhythm : the Official Journal of the Heart Rhythm Society
Christopher X WongPrashanthan Sanders

Abstract

Patients with lone atrial fibrillation (AF) have an abnormal atrial substrate. The purpose of this study was to determine the role of direction-dependent conduction in patients with lone AF. Twenty-four patients with paroxysmal lone AF and 24 reference patients with left-sided accessory pathways were studied. Multipolar catheters placed at the lateral right atrium, crista terminalis, coronary sinus (CS), and left atrial roof were used to determine direction-dependent conduction characteristics. Biatrial electroanatomic maps were created during sinus rhythm and with distal CS pacing to characterize direction-dependent differences in conduction velocities, electrogram complexity, and voltage. Differing wavefront directions caused changes in conduction velocity (P <.001), biatrial activation times (P <.001), electrogram fragmentation (P <.001), site-specific conduction delays (P <.001), and voltage (P <.001) in both lone AF and reference patients. These direction-dependent abnormalities were amplified in lone AF patients compared to reference patients, who exhibited greater slowing in conduction velocities (P = .02), prolongation of biatrial activation time (P = .04), increase in number (P <.001) and length (P <.001) of lines of c...Continue Reading

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May 15, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Dennis H LauPrashanthan Sanders

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Citations

Feb 7, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Christopher X WongPrashanthan Sanders
Apr 16, 2013·The American Journal of Cardiology·Christopher X WongPrashanthan Sanders
Apr 10, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Anthony G BrooksPrashanthan Sanders
Sep 12, 2015·Journal of Cardiovascular Electrophysiology·Junaid A B Zaman, Sanjiv M Narayan
Jun 26, 2012·Journal of the American College of Cardiology·Thomas M MungerYong-Mei Cha
Apr 29, 2014·International Journal of Cardiology·George DakosVassilios Vassilikos
Dec 8, 2016·Circulation. Arrhythmia and Electrophysiology·Christopher X WongRobert Clarke
Jun 24, 2017·Journal of Cardiovascular Electrophysiology·Steven E WilliamsMark O'Neill
May 12, 2019·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Iain SimSteven E Williams
Aug 3, 2017·Journal of Arrhythmia·Kazuki IsoMizuki Nikaido
Mar 6, 2021·Journal of Arrhythmia·Daisuke YakabeToshihiro Nakamura

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